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Infect Immun. 1973 March; 7(3): 461-467
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Interaction of Lymphoid and Nonlymphoid Cells with the Lymphocytosis-Promoting Factor of Bordetella pertussis

¹ Department of Microbiology and Immunology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203

ABSTRACT

The activity of soluble lymphocytosis-promoting factor (LPF) from Bordetella pertussis decreased after brief in vitro incubation with lymphoid cells or erythrocytes. The LPF activity was found to be associated with the cells used, and injection of the cells produced a leukocytosis and lymphocytosis which completely accounted for the loss of soluble activity. Attachment of LPF to cells was found to be reversible in vitro. It is suggested that reversible binding occurs in vivo.

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