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Infect Immun. 1973 March; 7(3): 476-478
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Galactose-Deficient Endotoxin from Urinary Escherichia coli

Department of Medicine and Pathology, University of California School of Medicine, San Diego, California 92103
Department of Medicine, University of Washington, Seattle, Washington 98105

ABSTRACT

Analysis of 111 rough strains of Escherichia coli from known urinary infections revealed for the first time that galactose-deficient rough mutants are not exclusively a laboratory phenomenon. They exist naturally with or without an epimerase deficiency and represent natural examples of the key role of galactose in the attachment of "O" side chains to the core of bacterial lipopolysaccharides.

¹ Present address: Department of Medicine, Yale-New Haven Medical Center, New Haven, Conn. 06510.