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Infect Immun. 1973 March; 7(3): 507-511
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Immunity to Salmonella typhimurium Infection: Characterization of Antigens in Active Protection by Polyacrylamide Gel Electrophoresis

^a Department of Microbiology, The George Washington University, School of Medicine, Washington, D.C. 20005

ABSTRACT

Immunity to challenge with Salmonella typhimurium (strain SR-11) was studied in NIH/NMRI Swiss mice. Viable organisms induced the best protection, but ribosomes were the best immunogen of the subcellular fractions. Antigens with lower concentrations of protein did not induce protection as well as antigens which had higher concentrations of protein. Acrylamide gel electrophoresis of the SR-11 subcellular components, fractionation, and differential staining of the gel columns indicated that the immunogen is a high-molecular-weight glycoprotein or mucopolysaccharide.

¹ Send reprint requests to present address: Immunotherapy and Immune Response Modifiers Section, Drug Evaluation Branch, Drug Research and Development, Division of Cancer Treatment, National Cancer Institute, Bethesda, Md. 20014.