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Infect Immun. 1973 April; 7(4): 567-572
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Biochemistry of Vibrio cholerae Virulence III. Nutritional Requirements for Toxin Production and the Effects of pH on Toxin Elaboration in Chemically Defined Media

Lynn T. Callahan III1 and Stephen H. Richardson

a Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103

ABSTRACT

The investigations described in this report concern the metabolic and physiologic parameters governing cholera enterotoxin production in chemically defined growth media. The results indicate that the minimal nutritional requirements for growth of pathogenic Vibrio cholerae are the same as those for toxin production, and that toxin production parallels growth of the organisms. Studies of the relationship between toxin accumulation and pH reveal that toxin biosynthesis can be separated from toxin release. Toxin is synthesized below pH 7.0, but release and accumulation of extracellular toxin occur only at neutral or alkaline pH values.

FOOTNOTES

1 Present address: Department of Microbiology, Naval Medical Research Institute, National Naval Medical Center, Bethesda, Md. 20014.

Infect Immun. 1973 April; 7(4): 567-572
Copyright © 1973 American Society for Microbiology. All Rights Reserved.



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