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Infect Immun. 1973 May; 7(5): 718-724
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Ribonucleic Acid and Protein Synthesis in Guinea Pig Liver During Q Fever

^a Department of Microbiology, University of Kansas, Lawrence, Kansas 66044

ABSTRACT

Protein and ribonucleic acid (RNA) syntheses increase in the liver during Q fever, coincident with progressive increments in cortisol levels. Cell-free protein-synthesizing systems indicate that the pH 5 enzyme fraction was chiefly responsible for enhanced activity. Although the polysome profiles from normal and infected livers were similar, the number of liver ribosomes doubled during infection. There was a concomitant increase in orotate incorporation in the 28s, 18s, and 4s RNA species of infected liver.

¹ Present address: Department of Biological Chemistry, California College of Medicine, University of California, Irvine, Calif. 92664.