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Infect Immun. 1973 May; 7(5): 743-746
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Specificity of a BCG-Induced Pulmonary Granulomatous Response in Rabbits

^a Department of Microbiology, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103

ABSTRACT

The specificity of Bacillus Calmette Guérin (BCG)-induced accelerated pulmonary granuloma formation has been evaluated in rabbits by cross sensitization-challenge experiments by using another granulomagenic organism, Corynebacterium granulosum. BCG-sensitized rabbits responded to challenge with homologous but not heterologous antigen, indicating that BCG-induced accelerated granuloma formation displays specificity characteristic of immunological reactions. These differences were also observed in local pulmonary delayed hypersensitivity, as determined by the migration inhibition test. The relationship between local pulmonary delayed hypersensitivity and the accelerated granulomatous response is discussed.

¹ Present address: Research Service, Veterans Administration Center, Wood, Wisconsin 53193.