This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Moore, V. L. Articles by Myrvik, Q. N. Search for Related Content PubMed PubMed Citation Articles by Moore, V. L. Articles by Myrvik, Q. N.

 Previous Article  |  Next Article 

Infect Immun. 1973 May; 7(5): 764-770
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Relationship of BCG-Induced Pulmonary Delayed Hypersensitivity to Accelerated Granuloma Formation in Rabbit Lungs: Effect of Cortisone Acetate

^a Department of Microbiology, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27103

ABSTRACT

The role of local pulmonary delayed hypersensitivity in accelerated pulmonary granuloma formation was investigated using cortisone acetate, an immunosuppressive drug that appears to preferentially eliminate committed lymphocytes at appropriate doses. Data are presented showing that cortisone acetate suppressed local pulmonary delayed hypersensitivity at the time of and subsequent to challenge with BCG. Furthermore, cortisone damage appeared to involve primarily committed lymphocyte populations since the defect was repairable with sensitized spleen cells, an unlikely source of macrophage precursors.

¹ Present address: Research Unit, Wood VA Hospital, Wood (Milwaukee), Wis. 53193.