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Infect Immun. 1973 June; 7(6): 1009-1011
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Enhanced Immune Response After Immunosuppression by Streptococcal Pyrogenic Exotoxin

¹ Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
Department of Microbiology, The Medical School, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

Streptococcal pyrogenic exotoxin (SPE) was shown previously to be a potent immunosuppressant. This paper presents data documenting that immunosuppression frequently was followed by elevated antibody and plaque-forming cell levels as noted in our earlier report. The data are interpreted as a differential effect of SPE upon suppressor T cells and secreting B cells.