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Infect Immun. 1973 June; 7(6): 898-904
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Host Defense Mechanisms Against Herpes Simplex Virus I. Control of Infection In Vitro by Sensitized Spleen Cells and Antibody

¹ Division of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118

ABSTRACT

Sensitized mouse spleen cells decrease the spread of herpes simplex virus infection in cell culture lines derived from human and murine tissues. These washed, sensitized cells act alone and additively in combination with antibody to diminish the ability of single virus-infected cells to spread infection to contiguous cells. This control of infection is not species specific, unlike interferon, and appears to be distinct from the effect of antibody. Lymphotoxin was not detected in this lymphocyte-mediated response. This control of herpes simplex virus infection in vitro by sensitized lymphoid cells is immunologically specific; spleen cells from donor animals immunized with a heterotypic virus do not cause herpesvirus plaque size reduction. The ratio of spleen cells from immunized animals to target monolayer cells needed to produce this effect is > 4:1. Plaque size reduction of herpes simplex virus by spleen cells requires intact, immune, non-glass-adhering lymphoid cells.