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Infect Immun. 1973 June; 7(6): 905-910
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Homogeneity of Venezuelan Encephalitis Virion Populations of Hamster-Virulent and Benign Strains, Including the Attenuated TC83 Vaccine

¹ Department of Microbiology, Cornell University Medical College, 1300 York Avenue, New York, New York 10021

ABSTRACT

A hamster-virulent strain of Venezuelan encephalitis virus (BeAn8, subtype III) and a benign strain (BeAr35645, subtype IV) each yielded 100 clones with virulence properties like those of the parental virion population. Another hamster-virulent strain (63U2, subtype I, variety E) was heterogeneous since 2 out of 100 clones were less virulent for hamsters than the other 98 clones or the parental virus population. The attenuated TC83 vaccine strain, (a derivative of subtype I, variety A), although over 99% homogeneous with respect to hamster virulence, was unstable since virulent virions could be selected from the parental population by passage through hamsters.