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Infection and Immunity, January 2002, p. 233-239, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.233-239.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Increased CD8+-T-Cell Expression and a Type 2 Cytokine Pattern during the Muscular Phase of Trichinella Infection in Humans

Maria Angeles Gomez Morales,1 Raffaella Mele,1 Massimo Sanchez,2 Daria Sacchini,3 Marzia De Giacomo,1 and Edoardo Pozio1*

Laboratory of Parasitology,1 Laboratory of Cellular Biology, Istituto Superiore di Sanità, Rome,2 Unità Operativa Malattie Infettive, Azienda Unità Sanitaria Locale, Piacenza, Italy3

Received 26 April 2001/ Returned for modification 28 June 2001/ Accepted 5 October 2001

Cell-mediated immunity during the muscular phase of Trichinella infection in humans was studied. Cell proliferation, the phenotypic changes in the T-cell population, and expression and production of cytokines were examined by using peripheral blood mononuclear cells (PBMC) collected at different times postinfection from 10 individuals who had acquired Trichinella spiralis and five individuals who had acquired Trichinella britovi in two distinct outbreaks. T. spiralis and T. britovi crude worm extracts induced proliferation of PBMC from T. spiralis- and T. britovi-infected donors. Cytokine gene expression showed a predominant type 2 pattern for the entire period of infection studied, although gamma interferon (IFN-{gamma}) was expressed. Interleukin-2 (IL-2), IL-5, IL-10, and IFN-{gamma} production was found in PBMC of all donors. There was a good correspondence between the cytokine expression and production patterns. Changes in PBMC composition, with a trend toward an increase in CD8+ lymphocyte counts, were observed.

* Corresponding author. Mailing address: Laboratory of Parasitology, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 06 4990 2304. Fax: 39 06 4938 7065. E-mail: pozio{at}iss.it.

Editor: T. R. Kozel

Infection and Immunity, January 2002, p. 233-239, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.233-239.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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