This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duthie, M. S.
Right arrow Articles by Kahn, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duthie, M. S.
Right arrow Articles by Kahn, S. J.

 Previous Article  |  Next Article 

Infection and Immunity, January 2002, p. 36-48, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.36-48.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

During Trypanosoma cruzi Infection CD1d-Restricted NK T Cells Limit Parasitemia and Augment the Antibody Response to a Glycophosphoinositol-Modified Surface Protein

Malcolm S. Duthie,1 Monika Wleklinski-Lee,1 Sherilyn Smith,1 Toshinori Nakayama,2 Masaru Taniguchi,2 and Stuart J. Kahn1,3*

Departments of Pediatrics,1 Department of Molecular Immunology, Chiba University, Chiba, Japan,2 Pathobiology, University of Washington, Seattle, Washington 981953

Received 18 May 2001/ Returned for modification 25 July 2001/ Accepted 1 October 2001

Trypanosoma cruzi is a protozoan parasite that chronically infects many mammalian species and in humans causes Chagas’ disease, a chronic inflammatory disease. The parasite expresses glycophosphoinositol (GPI), which potently stimulates interleukin 12 (IL-12) production. During T. cruzi infection IL-12, and possibly GPI, might stimulate NK T cells to affect the protective and chronic inflammatory responses. Here we report that during T. cruzi infection CD1d-restricted NK T cells are stimulated as NK T-cell-deficient mice have greater parasitemia. Furthermore, during T. cruzi infection the percentages of NK T cells in the liver and spleen become decreased for prolonged periods of time, and in vitro stimulation of NK T cells derived from livers of chronically infected mice, compared to uninfected mice, results in increased gamma interferon and IL-4 secretion. Moreover, in NK T-cell-deficient mice the chronic-phase antibody response to a GPI-modified surface protein is decreased. These results indicate that, during the acute infection, NK T cells limit parasitemia and that, during the chronic phase, NK T cells augment the antibody response. Thus, during T. cruzi infection the quality of an individual’s NK T-cell response can affect the level of parasitemia and parasite tissue burden, the intensity of the chronic inflammatory responses, and possibly the outcome of Chagas’ disease.

* Corresponding author. Mailing address: Department of Pediatrics, University of Washington, Box 356320, 1959 N.E. Pacific St., Seattle, WA 98195-6320. Phone: (206) 543-4424. Fax: (206) 221-5469. E-mail: stujk{at}u.washington.edu.

Editor: J. M. Mansfield

Infection and Immunity, January 2002, p. 36-48, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.36-48.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • de Alencar, B. C. G., Persechini, P. M., Haolla, F. A., de Oliveira, G., Silverio, J. C., Lannes-Vieira, J., Machado, A. V., Gazzinelli, R. T., Bruna-Romero, O., Rodrigues, M. M. (2009). Perforin and Gamma Interferon Expression Are Required for CD4+ and CD8+ T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination. Infect. Immun. 77: 4383-4395 [Abstract] [Full Text]  
  • Renukaradhya, G. J., Khan, M. A., Shaji, D., Brutkiewicz, R. R. (2008). Vesicular Stomatitis Virus Matrix Protein Impairs CD1d-Mediated Antigen Presentation through Activation of the p38 MAPK Pathway. J. Virol. 82: 12535-12542 [Abstract] [Full Text]  
  • Medeiros, M. M., Peixoto, J. R., Oliveira, A.-C., Cardilo-Reis, L., Koatz, V. L. G., Van Kaer, L., Previato, J. O., Mendonca-Previato, L., Nobrega, A., Bellio, M. (2007). Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol. 82: 488-496 [Abstract] [Full Text]  
  • Duthie, M. S., Kahn, M., Zakayan, A., White, M., Kahn, S. J. (2007). Parasite-Induced Chronic Inflammation Is Not Exacerbated by Immunotherapy before or during Trypanosoma cruzi Infection. CVI 14: 1005-1012 [Abstract] [Full Text]  
  • Mallevaey, T., Fontaine, J., Breuilh, L., Paget, C., Castro-Keller, A., Vendeville, C., Capron, M., Leite-de-Moraes, M., Trottein, F., Faveeuw, C. (2007). Invariant and Noninvariant Natural Killer T Cells Exert Opposite Regulatory Functions on the Immune Response during Murine Schistosomiasis. Infect. Immun. 75: 2171-2180 [Abstract] [Full Text]  
  • Sardinha, L. R., Elias, R. M., Mosca, T., Bastos, K. R. B., Marinho, C. R. F., D'Imperio Lima, M. R., Alvarez, J. M. (2006). Contribution of NK, NK T, {gamma}{delta} T, and {alpha}{beta} T Cells to the Gamma Interferon Response Required for Liver Protection against Trypanosoma cruzi. Infect. Immun. 74: 2031-2042 [Abstract] [Full Text]  
  • Svensson, M., Zubairi, S., Maroof, A., Kazi, F., Taniguchi, M., Kaye, P. M. (2005). Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection. Infect. Immun. 73: 7541-7547 [Abstract] [Full Text]  
  • Hoft, D. F., Eickhoff, C. S. (2005). Type 1 Immunity Provides Both Optimal Mucosal and Systemic Protection against a Mucosally Invasive, Intracellular Pathogen. Infect. Immun. 73: 4934-4940 [Abstract] [Full Text]  
  • Smiley, S. T., Lanthier, P. A., Couper, K. N., Szaba, F. M., Boyson, J. E., Chen, W., Johnson, L. L. (2005). Exacerbated Susceptibility to Infection-Stimulated Immunopathology in CD1d-Deficient Mice. J. Immunol. 174: 7904-7911 [Abstract] [Full Text]  
  • Duthie, M. S., Kahn, S. J. (2005). NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection. Int Immunol 17: 607-613 [Abstract] [Full Text]  
  • Duthie, M. S., Kahn, M., White, M., Kapur, R. P., Kahn, S. J. (2005). Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection. Infect. Immun. 73: 1890-1894 [Abstract] [Full Text]  
  • Lin, Y., Roberts, T. J., Spence, P. M., Brutkiewicz, R. R. (2005). Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection. J. Leukoc. Biol. 77: 151-158 [Abstract] [Full Text]  
  • Duthie, M. S., Kahn, M., White, M., Kapur, R. P., Kahn, S. J. (2005). Critical Proinflammatory and Anti-Inflammatory Functions of Different Subsets of CD1d-Restricted Natural Killer T Cells during Trypanosoma cruzi Infection. Infect. Immun. 73: 181-192 [Abstract] [Full Text]  
  • Parekh, V. V., Singh, A. K., Wilson, M. T., Olivares-Villagomez, D., Bezbradica, J. S., Inazawa, H., Ehara, H., Sakai, T., Serizawa, I., Wu, L., Wang, C.-R., Joyce, S., Van Kaer, L. (2004). Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct {alpha}- and {beta}-Anomeric Glycolipids. J. Immunol. 173: 3693-3706 [Abstract] [Full Text]  
  • Matsuda, J. L., Gapin, L., Baron, J. L., Sidobre, S., Stetson, D. B., Mohrs, M., Locksley, R. M., Kronenberg, M. (2003). Mouse V{alpha}14i natural killer T cells are resistant to cytokine polarization in vivo. Proc. Natl. Acad. Sci. USA 100: 8395-8400 [Abstract] [Full Text]  
  • Miyahira, Y., Katae, M., Takeda, K., Yagita, H., Okumura, K., Kobayashi, S., Takeuchi, T., Kamiyama, T., Fukuchi, Y., Aoki, T. (2003). Activation of Natural Killer T Cells by {alpha}-Galactosylceramide Impairs DNA Vaccine-Induced Protective Immunity against Trypanosoma cruzi. Infect. Immun. 71: 1234-1241 [Abstract] [Full Text]  
  • Grubor-Bauk, B., Simmons, A., Mayrhofer, G., Speck, P. G. (2003). Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant V{alpha}14-J{alpha}281 TCR. J. Immunol. 170: 1430-1434 [Abstract] [Full Text]  
  • Procopio, D. O., Almeida, I. C., Torrecilhas, A. C. T., Cardoso, J. E., Teyton, L., Travassos, L. R., Bendelac, A., Gazzinelli, R. T. (2002). Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins from Trypanosoma cruzi Bind to CD1d but Do Not Elicit Dominant Innate or Adaptive Immune Responses Via the CD1d/NKT Cell Pathway. J. Immunol. 169: 3926-3933 [Abstract] [Full Text]  
  • Duthie, M. S., Kahn, S. J. (2002). Treatment with {alpha}-Galactosylceramide Before Trypanosoma cruzi Infection Provides Protection or Induces Failure to Thrive. J. Immunol. 168: 5778-5785 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»