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Production of Prostaglandins and Leukotrienes by Pathogenic Fungi

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,¹ Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0642²

Received 29 June 2001/ Returned for modification 9 August 2001/ Accepted 27 September 2001

These studies demonstrate that pathogenic fungi (dermatophytic, subcutaneous, and systemic) have the ability to produce eicosanoids both from simple metabolites and from arachidonic acid. Host-derived eicosanoids have been previously demonstrated to enhance fungal colonization and atopic disease development. Thus, fungus-derived eicosanoids represent a potential class of novel virulence factors.

Editor: T. R. Kozel

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