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Infection and Immunity, January 2002, p. 416-418, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.416-418.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

STK Receptor Tyrosine Kinase Regulates Susceptibility to Infection with Listeria monocytogenes

Michael A. Lutz,1 Francine Gervais,2 Alan Bernstein,3 Arthur L. Hattel,1 and Pamela H. Correll1*

Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3500,1 Montreal General Hospital Research Institute, Centre for the Study of Host Resistance, Montreal, Quebec H3G 1A4,2 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada3

Received 15 June 2001/ Returned for modification 23 August 2001/ Accepted 4 October 2001

We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria.

* Corresponding author. Mailing address: Department of Veterinary Science, The Pennsylvania State University, 115 Henning Bldg., University Park, PA 16802-3500. Phone: (814) 863-0128. Fax: (814) 863-6140. E-mail: phc7{at}psu.edu.

Editor: V. J. DiRita

Infection and Immunity, January 2002, p. 416-418, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.416-418.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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