This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lutz, M. A. Articles by Correll, P. H. Search for Related Content PubMed PubMed Citation Articles by Lutz, M. A. Articles by Correll, P. H.

STK Receptor Tyrosine Kinase Regulates Susceptibility to Infection with Listeria monocytogenes

Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802-3500,¹ Montreal General Hospital Research Institute, Centre for the Study of Host Resistance, Montreal, Quebec H3G 1A4,² Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada³

Received 15 June 2001/ Returned for modification 23 August 2001/ Accepted 4 October 2001

We have previously identified the STK receptor tyrosine kinase as a key regulator of macrophage activation and cell-mediated immune responses. Here we demonstrate that, although MSP activation of STK inhibits NO production by macrophages in response to heat-killed Listeria monocytogenes, STK-deficient mice exhibit increased susceptibility to infection with Listeria.

Editor: V. J. DiRita

This article has been cited by other articles:

• Kalantari, P., Harandi, O. F., Hankey, P. A., Henderson, A. J. (2008). HIV-1 Tat Mediates Degradation of RON Receptor Tyrosine Kinase, a Regulator of Inflammation. J. Immunol. 181: 1548-1555 [Abstract] [Full Text]  
• Lee, E. S., Kalantari, P., Tsutsui{section}, S., Klatt, A., Holden, J., Correll, P. H., Power{section}, C., Henderson, A. J. (2004). RON Receptor Tyrosine Kinase, a Negative Regulator of Inflammation, Inhibits HIV-1 Transcription in Monocytes/Macrophages and Is Decreased in Brain Tissue from Patients with AIDS. J. Immunol. 173: 6864-6872 [Abstract] [Full Text]  
• Correll, P. H., Morrison, A. C., Lutz, M. A. (2004). Receptor tyrosine kinases and the regulation of macrophage activation. J. Leukoc. Biol. 75: 731-737 [Full Text]  
• Forgie, A., Wyatt, S., Correll, P. H., Davies, A. M. (2003). Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons. Development 130: 995-1002 [Abstract] [Full Text]