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Isolation and Properties of Stachyrase A, a Chymotrypsin-Like Serine Proteinase from Stachybotrys chartarum

Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio 44115,¹ Institute of Molecular Biology, Jagiellonian University, 31-120 Cracow, Poland,² Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, Georgia 30602³

Received 27 June 2001/ Returned for modification 7 August 2001/ Accepted 15 October 2001

A strain of the common mold Stachybotrys chartarum has been isolated from the lung of a child with pulmonary hemorrhage. We report the purification of stachyrase A, a new serine chymotrypsin-like proteinase from S. chartarum. This enzyme cleaves major protease inhibitors, several biologically active peptides, and collagen, all of which are found in the lung.

Editor: D. L. Burns

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