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Infection and Immunity, January 2002, p. 419-421, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.419-421.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Isolation and Properties of Stachyrase A, a Chymotrypsin-Like Serine Proteinase from Stachybotrys chartarum

Tomasz Kordula,1 Agnieszka Banbula,2 Jeremy Macomson,3 and James Travis3,2*

Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio 44115,1 Institute of Molecular Biology, Jagiellonian University, 31-120 Cracow, Poland,2 Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, Georgia 306023

Received 27 June 2001/ Returned for modification 7 August 2001/ Accepted 15 October 2001

A strain of the common mold Stachybotrys chartarum has been isolated from the lung of a child with pulmonary hemorrhage. We report the purification of stachyrase A, a new serine chymotrypsin-like proteinase from S. chartarum. This enzyme cleaves major protease inhibitors, several biologically active peptides, and collagen, all of which are found in the lung.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, GA 30602. Phone: (706) 542-1713. Fax: (706) 542-1738. E-mail: JTravis{at}arches.uga.edu.

Editor: D. L. Burns

Infection and Immunity, January 2002, p. 419-421, Vol. 70, No. 1
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.1.419-421.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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