This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gumenscheimer, M.
Right arrow Articles by Freudenberg, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gumenscheimer, M.
Right arrow Articles by Freudenberg, M. A.

 Previous Article  |  Next Article 

Infection and Immunity, October 2002, p. 5596-5603, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5596-5603.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Beneficial or Deleterious Effects of a Preexisting Hypersensitivity to Bacterial Components on the Course and Outcome of Infection

Marina Gumenscheimer, Ivan Mitov, Chris Galanos, and Marina A. Freudenberg*

Max-Planck-Institut für Immunbiologie, 79 108 Freiburg, Germany

Received 9 April 2002/ Returned for modification 6 June 2002/ Accepted 1 July 2002

Priming with heat-killed Propionibacterium acnes enhances the sensitivity of mice to lipopolysaccharide (LPS) and other biologically active bacterial components. We show that P. acnes priming has protective and deleterious effects on a subsequent serovar Typhimurium infection. It may result in a complete protection or prolonged survival, or it may accelerate mortality of the infected mice, depending on the number of serovar Typhimurium bacteria administered and on the degree of LPS hypersensitivity at the time of infection. Both effects of P. acnes-induced hypersensitivity are mediated by gamma interferon (IFN-{gamma}) and are based on a differential activation of the innate immune mechanisms which recognize and react against the LPS present in infecting bacteria. In P. acnes-primed mice null for LPS-binding protein (LBP-/- mice), the impaired LPS recognition, due to the absence of LBP, resulted in a higher resistance to serovar Typhimurium infection. A similar P. acnes priming of mice had a protective, but no deleterious effect on a subsequent L. monocytogenes infection. This effect was IFN-{gamma} dependent but independent of LBP.

* Corresponding author. Mailing address: Max-Planck-Institut für Immunbiologie, Stübeweg 51, 79 108 Freiburg/Br., Germany. Phone: 49 761 5108 404. Fax: 49 761 5108 403. E-mail: freudenberg{at}immunbio.mpg.de.

Editor: J. D. Clements

Infection and Immunity, October 2002, p. 5596-5603, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5596-5603.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kalis, C., Gumenscheimer, M., Freudenberg, N., Tchaptchet, S., Fejer, G., Heit, A., Akira, S., Galanos, C., Freudenberg, M. A. (2005). Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes. J. Immunol. 174: 4295-4300 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»