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Infection and Immunity, October 2002, p. 5857-5859, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5857-5859.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Requirement for Tumor Necrosis Factor Receptor 2 Expression on Vascular Cells To Induce Experimental Cerebral Malaria

Benjamin Stoelcker,1 Thomas Hehlgans,1 Karin Weigl,1 Horst Bluethmann,2 Georges E. Grau,3 and Daniela N. Männel1*

Institute of Pathology/Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany,1 Pharmaceutical Research Gene Technology, F. Hoffmann-LaRoche Ltd., 4002 Basel, Switzerland,2 Experimental Parasitology Unit, Faculties of Medicine and Pharmacie, Université de la Mediterranée, 13385 Marseille, France3

Received 19 March 2002/ Returned for modification 7 May 2002/ Accepted 20 June 2002

Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.

* Corresponding author. Mailing address: Institute of Pathology/Tumor Immunology, University of Regensburg, Franz-Josef Strauß Allee 11, 93042 Regensburg, Germany. Phone: 49-941-944 6622. Fax: 49-941-944 6602. E-mail: daniela.maennel{at}klinik.uni-regensburg.de.

Editor: S. H. E. Kaufmann

Infection and Immunity, October 2002, p. 5857-5859, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5857-5859.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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