Previous Article | Next Article 
Infection and Immunity, October 2002, p. 5857-5859, Vol. 70, No. 10
0019-9567/02/$04.00+0 DOI: 10.1128/IAI.70.10.5857-5859.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.
Requirement for Tumor Necrosis Factor Receptor 2 Expression on Vascular Cells To Induce Experimental Cerebral Malaria
Benjamin Stoelcker,1 Thomas Hehlgans,1 Karin Weigl,1 Horst Bluethmann,2 Georges E. Grau,3 and Daniela N. Männel1*
Institute of Pathology/Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany,1
Pharmaceutical Research Gene Technology, F. Hoffmann-LaRoche Ltd., 4002 Basel, Switzerland,2
Experimental Parasitology Unit, Faculties of Medicine and Pharmacie, Université de la Mediterranée, 13385 Marseille, France3
Received 19 March 2002/
Returned for modification 7 May 2002/
Accepted 20 June 2002
Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.
* Corresponding author. Mailing address: Institute of Pathology/Tumor Immunology, University of Regensburg, Franz-Josef Strauß Allee 11, 93042 Regensburg, Germany. Phone: 49-941-944 6622. Fax: 49-941-944 6602. E-mail:
daniela.maennel{at}klinik.uni-regensburg.de.
Editor: S. H. E. Kaufmann
Infection and Immunity, October 2002, p. 5857-5859, Vol. 70, No. 10
0019-9567/02/$04.00+0 DOI: 10.1128/IAI.70.10.5857-5859.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Martini, J., Gramaglia, I., Intaglietta, M., van der Heyde, H. C.
(2007). Impairment of Functional Capillary Density but Not Oxygen Delivery in the Hamster Window Chamber during Severe Experimental Malaria. Am. J. Pathol.
170: 505-517
[Abstract]
[Full Text]
-
Giese, A., Stuhlsatz, S., Daubener, W., MacKenzie, C. R.
(2004). Inhibition of the Growth of Toxoplasma gondii in Immature Human Dendritic Cells Is Dependent on the Expression of TNF-{alpha} Receptor 2. J. Immunol.
173: 3366-3374
[Abstract]
[Full Text]
-
Mizgerd, J. P., Lupa, M. M., Hjoberg, J., Vallone, J. C., Warren, H. B., Butler, J. P., Silverman, E. S.
(2004). Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am. J. Physiol. Lung Cell. Mol. Physiol.
286: L1302-L1310
[Abstract]
[Full Text]
-
Combes, V., Rosenkranz, A. R., Redard, M., Pizzolato, G., Lepidi, H., Vestweber, D., Mayadas, T. N., Grau, G. E.
(2004). Pathogenic Role of P-Selectin in Experimental Cerebral Malaria: Importance of the Endothelial Compartment. Am. J. Pathol.
164: 781-786
[Abstract]
[Full Text]