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Infection and Immunity, October 2002, p. 5860-5864, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5860-5864.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chlamydial Antigens Colocalize within IncA-Laden Fibers Extending from the Inclusion Membrane into the Host Cytosol{dagger}

W. J. Brown,1 Y. A. W. Skeiky,2 P. Probst,2 and D. D. Rockey1*

Department of Microbiology, Oregon State University, Corvallis, Oregon 97331,1 Corixa Corporation, Seattle, Washington 981042

Received 20 March 2002/ Returned for modification 19 April 2002/ Accepted 15 July 2002

Chlamydial IncA localizes to the inclusion membrane and to vesicular fibers extending away from the inclusion. Chlamydial outer membrane components, in the absence of developmental forms, are found within these fibers. This colocalization may explain how chlamydial developmental form antigens are localized outside of the inclusion within infected cells.

* Corresponding author. Mailing address: Department of Microbiology, Oregon State University, Corvallis, OR 97331-3804. Phone: (541) 737-1848. Fax: (541) 737-0496. E-mail: rockeyd{at}orst.edu.

{dagger} Oregon State University Agricultural Experiment Station technical paper 11778.

Editor: J. D. Clements

Infection and Immunity, October 2002, p. 5860-5864, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5860-5864.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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