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Infection and Immunity, October 2002, p. 5865-5869, Vol. 70, No. 10
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.10.5865-5869.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Uropathogenicity Island Contributes to the Pathogenicity of Escherichia coli Strains That Cause Neonatal Meningitis

Laboratoire d'Études de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Hôpital Robert Debré, 75019 Paris,¹ INSERM U 570, Faculté de Médecine Necker-Enfants Malades, 75730 Paris cedex 15, France²

Received 19 February 2002/ Returned for modification 14 May 2002/ Accepted 2 July 2002

We report that the archetypal Escherichia coli strain C5 causing neonatal meningitis harbors a pathogenicity island (PAI) designated PAI I_C5 that is similar to the PAI II_J96 of uropathogenic E. coli J96 inserted in the leuX-tRNA gene. PAI-negative C5 mutants had a lower capacity than C5 to induce high-level bacteremia in a neonatal rat model. However, no change in their resistance to the bactericidal effect of serum and their capacity to cross the blood-brain barrier was observed.

Editor: V. J. DiRita

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