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Infection and Immunity, November 2002, p. 6058-6067, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6058-6067.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Modulation of a Heterologous Immune Response by the Products of Ascaris suum

Jacqueline C. M. Paterson,1 Paul Garside,2 Malcolm W. Kennedy,3 and Catherine E. Lawrence4*

Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital, Dundee DD1 9SY,1 Department of Immunology and Bacteriology, Western Infirmary, Glasgow G11 6NT,2 Division of Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ,3 Department of Immunology, Strathclyde University, Glasgow G4 0NR, United Kingdom4

Received 23 January 2002/ Returned for modification 30 April 2002/ Accepted 2 August 2002

Helminth infections are among the most potent stimulators of Th2-type immune responses and have been widely demonstrated to modify responsiveness to both nonparasite antigens and other infectious agents in a nonspecific manner in infected animals. We investigated the immunomodulatory properties of pseudocoelomic body fluid from adult Ascaris suum gastrointestinal helminths (ABF) and its defined allergen (ABA-1) by examining their effects on the immune response to a heterologous antigen, ovalbumin. Our results indicate that ABF has potent immunomodulatory activity and that the effects observed are consistent with skewing towards a Th2-type response rather than induction of anergy. Our findings show that the immunomodulatory activities of ABF are associated with components other than the major constituent and putative allergen, ABA-1. Furthermore, the allergic responses to ABA-1 are not a result of an intrinsic allergenicity of the protein but are more a reflection of the wider induction of a Th2 response by the infection. Importantly, the induction of interleukin-10 by ABF also suggests that T regulatory cells may play a role in immunomodulation of immune responses by parasitic helminths.

* Corresponding author. Mailing address: Department of Immunology, Todd Wing, SIBS, Strathclyde University, 27 Taylor Street, Glasgow G4 0NR, United Kingdom. Phone: 44 141 548 2104. Fax: 44 141 548 3748. E-mail: catherine.lawrence{at}strath.ac.uk.

Editor: J. M. Mansfield

Infection and Immunity, November 2002, p. 6058-6067, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6058-6067.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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