This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An author's correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fudyk, T.
Right arrow Articles by Stephens, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fudyk, T.
Right arrow Articles by Stephens, R. S.

 Previous Article  |  Next Article 

Infection and Immunity, November 2002, p. 6444-6447, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6444-6447.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Selection of Mutant Cell Lines Resistant to Infection by Chlamydia trachomatis and Chlamydia pneumoniae

Trevor Fudyk,1 Lynn Olinger,2 and Richard S. Stephens1,2*

Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720,1 Francis I. Proctor Foundation, University of California, San Francisco, California 941432

Received 11 June 2002/ Returned for modification 23 July 2002/ Accepted 31 July 2002

The lytic outcome of natural infection by Chlamydia trachomatis was exploited to select CHO (Chinese hamster ovary) cells, following chemical mutagenesis, that were deficient in their ability to sustain productive chlamydial infection. Four distinct mutant cell phenotypes with defects in either attachment or postattachment mechanisms that are required for infection by C. trachomatis and Chlamydia pneumoniae were characterized.

* Corresponding author. Mailing address: Division of Infectious Diseases, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720-7360. Phone: (510) 643-9900. Fax: (510) 643-1537. E-mail: rss{at}uclink4.berkeley.edu.

Editor: D. L. Burns

Infection and Immunity, November 2002, p. 6444-6447, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6444-6447.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Swanson, K. A., Crane, D. D., Caldwell, H. D. (2007). Chlamydia trachomatis Species-Specific Induction of Ezrin Tyrosine Phosphorylation Functions in Pathogen Entry. Infect. Immun. 75: 5669-5677 [Abstract] [Full Text]  
  • Hybiske, K., Stephens, R. S. (2007). Mechanisms of Chlamydia trachomatis Entry into Nonphagocytic Cells. Infect. Immun. 75: 3925-3934 [Abstract] [Full Text]  
  • Clifton, D. R., Dooley, C. A., Grieshaber, S. S., Carabeo, R. A., Fields, K. A., Hackstadt, T. (2005). Tyrosine Phosphorylation of the Chlamydial Effector Protein Tarp Is Species Specific and Not Required for Recruitment of Actin. Infect. Immun. 73: 3860-3868 [Abstract] [Full Text]  
  • Gabel, B. R., Elwell, C., van Ijzendoorn, S. C. D., Engel, J. N. (2004). Lipid Raft-Mediated Entry Is Not Required for Chlamydia trachomatis Infection of Cultured Epithelial Cells. Infect. Immun. 72: 7367-7373 [Abstract] [Full Text]  
  • Engel, J. (2004). Tarp and Arp: How Chlamydia induces its own entry. Proc. Natl. Acad. Sci. USA 101: 9947-9948 [Full Text]  
  • Clifton, D. R., Fields, K. A., Grieshaber, S. S., Dooley, C. A., Fischer, E. R., Mead, D. J., Carabeo, R. A., Hackstadt, T. (2004). From The Cover: A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin. Proc. Natl. Acad. Sci. USA 101: 10166-10171 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»