This Article Full Text Full Text (PDF) An author's correction has been published Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fudyk, T. Articles by Stephens, R. S. Search for Related Content PubMed PubMed Citation Articles by Fudyk, T. Articles by Stephens, R. S.

 Previous Article  |  Next Article 

Infection and Immunity, November 2002, p. 6444-6447, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6444-6447.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Selection of Mutant Cell Lines Resistant to Infection by Chlamydia trachomatis and Chlamydia pneumoniae

Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California 94720,¹ Francis I. Proctor Foundation, University of California, San Francisco, California 94143²

Received 11 June 2002/ Returned for modification 23 July 2002/ Accepted 31 July 2002

The lytic outcome of natural infection by Chlamydia trachomatis was exploited to select CHO (Chinese hamster ovary) cells, following chemical mutagenesis, that were deficient in their ability to sustain productive chlamydial infection. Four distinct mutant cell phenotypes with defects in either attachment or postattachment mechanisms that are required for infection by C. trachomatis and Chlamydia pneumoniae were characterized.

Editor: D. L. Burns

This article has been cited by other articles:

• Swanson, K. A., Crane, D. D., Caldwell, H. D. (2007). Chlamydia trachomatis Species-Specific Induction of Ezrin Tyrosine Phosphorylation Functions in Pathogen Entry. Infect. Immun. 75: 5669-5677 [Abstract] [Full Text]  
• Hybiske, K., Stephens, R. S. (2007). Mechanisms of Chlamydia trachomatis Entry into Nonphagocytic Cells. Infect. Immun. 75: 3925-3934 [Abstract] [Full Text]  
• Clifton, D. R., Dooley, C. A., Grieshaber, S. S., Carabeo, R. A., Fields, K. A., Hackstadt, T. (2005). Tyrosine Phosphorylation of the Chlamydial Effector Protein Tarp Is Species Specific and Not Required for Recruitment of Actin. Infect. Immun. 73: 3860-3868 [Abstract] [Full Text]  
• Gabel, B. R., Elwell, C., van Ijzendoorn, S. C. D., Engel, J. N. (2004). Lipid Raft-Mediated Entry Is Not Required for Chlamydia trachomatis Infection of Cultured Epithelial Cells. Infect. Immun. 72: 7367-7373 [Abstract] [Full Text]  
• Engel, J. (2004). Tarp and Arp: How Chlamydia induces its own entry. Proc. Natl. Acad. Sci. USA 101: 9947-9948 [Full Text]  
• Clifton, D. R., Fields, K. A., Grieshaber, S. S., Dooley, C. A., Fischer, E. R., Mead, D. J., Carabeo, R. A., Hackstadt, T. (2004). From The Cover: A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin. Proc. Natl. Acad. Sci. USA 101: 10166-10171 [Abstract] [Full Text]