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Infection and Immunity, November 2002, p. 6460-6463, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6460-6463.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Association of Pasteurella multocida Toxin with Vimentin

Hiroaki Shime,1 Takahiro Ohnishi,2 Kaori Nagao,1 Kiyomasa Oka,1 Toshifumi Takao,3 and Yasuhiko Horiguchi1*

Department of Bacterial Toxinology, Research Institute for Microbial Diseases,1 Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871,3 Division of Microbiology, National Institute of Health Sciences, Setagaya, Tokyo 158-8501, Japan2

Received 14 May 2002/ Returned for modification 10 July 2002/ Accepted 29 July 2002

To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th amino acids of the toxin. This protein was identified as vimentin by peptide mass fingerprinting. The N-terminal head domain of vimentin was further found to be responsible for the binding to the toxin.

* Corresponding author. Mailing address: Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-8284. Fax: 81-6-6879-8283. E-mail: horiguti{at}biken.osaka-u.ac.jp.

Editor: J. T. Barbieri

Infection and Immunity, November 2002, p. 6460-6463, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6460-6463.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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