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Infection and Immunity, November 2002, p. 6471-6474, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6471-6474.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Parenteral Administration of Medium- but Not Long-Chain Lipid Emulsions May Increase the Risk for Infections by Candida albicans

Geert J. Wanten,1* Mihai G. Netea,2 Ton H. Naber,1 Jo H. Curfs,3 Liesbeth E. Jacobs,2 Trees J. Verver-Jansen,2 and Bart-Jan Kullberg2

Departments of Gastroenterology and Hepatology,1 Internal Medicine,2 Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands3

Received 26 October 2001/ Returned for modification 26 December 2001/ Accepted 5 August 2002

Intravenous administration to volunteers of an emulsion of medium-chain lipids, but not of an emulsion of pure long-chain lipids or a placebo, increased the growth of Candida albicans in serum and modulated Candida-induced cytokine production by mononuclear cells in a way suggesting that medium-chain, but not long-chain, triglycerides increase the risk for infections by Candida.

* Corresponding author. Mailing address: Department of Gastroenterology and Hepatology, University Medical Center Nijmegen, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands. Phone: 31243614760. Fax: 31243540103. E-mail: G.Wanten{at}gastro.azn.nl.

Editor: T. R. Kozel

Infection and Immunity, November 2002, p. 6471-6474, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6471-6474.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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