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Infection and Immunity, November 2002, p. 6489-6493, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6489-6493.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Differences in Rate and Variability of Intracellular Growth of a Panel of Mycobacterium tuberculosis Clinical Isolates within a Human Monocyte Model

Qing Li,1 Christopher C. Whalen,1,2,3 Jeffrey M. Albert,2 Rhonda Larkin,1 Lynn Zukowski,1 M. Donald Cave,4 and Richard F. Silver1,3*

Department of Medicine,1 Department of Epidemiology and Biostatistics,2 Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio,3 University of Arkansas for Medical Sciences, Little Rock, Arkansas4

Received 7 November 2001/ Returned for modification 7 January 2002/ Accepted 6 August 2002

Significant differences were observed in the capacities of Mycobacterium tuberculosis clinical isolates to grow within human monocytes. Genotyping indicated that the four most rapidly growing isolates were members of the Beijing strain family. M. tuberculosis strain H37Rv provided more reproducible infection than the clinical isolates or M. tuberculosis Erdman.

* Corresponding author. Mailing address: Divisions of Pulmonary and Critical Care Medicine and Infectious Diseases, Biomedical Research Building, Room 1030, Case Western Reserve University School of Medicine, 10900 Euclid Ave., Cleveland, OH 44106-4984. Phone: (216) 368-1151. Fax: (216) 368-2034. E-mail: rfs4{at}po.cwru.edu.

Editor: S. H. E. Kaufmann

Infection and Immunity, November 2002, p. 6489-6493, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6489-6493.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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