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Infection and Immunity, November 2002, p. 6494-6498, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6494-6498.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Comparison of Murine and Human Immunoproteomes of Helicobacter pylori Validates the Preclinical Murine Infection Model for Antigen Screening

Dirk Bumann,1 Petra Holland,1 Frank Siejak,2 Jan Koesling,1 Nicolas Sabarth,1 Stefanie Lamer,2 Ursula Zimny-Arndt,2 Peter R. Jungblut,2 and Thomas F. Meyer1*

Department of Molecular Biology,1 Central Core Facility Protein Analysis, Max-Planck-Institute for Infection Biology, Berlin, Germany2

Received 12 February 2002/ Returned for modification 8 April 2002/ Accepted 22 July 2002

Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter pylori immunoproteomes of infected mice with previously reported patient data reveals a high agreement in the antigens recognized, suggesting that H. pylori in vivo protein composition and recognition by the host immune system are comparable in mice and humans. Murine Helicobacter models may thus be valid to screen antigens for human vaccination.

* Corresponding author. Mailing address: Abteilung Molekulare Biologie, Max-Planck-Institut für Infektionsbiologie, Schumannstraße 21/22, D-10117 Berlin, Germany. Phone: 49 30 28460 400. Fax: 49 30 28460 401. E-mail: meyer{at}mpiib-berlin.mpg.de.

Editor: E. I. Tuomanen

Infection and Immunity, November 2002, p. 6494-6498, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6494-6498.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Copyright © 2002 by the American Society for Microbiology. All rights reserved.