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Infection and Immunity, November 2002, p. 6499-6503, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6499-6503.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Multiparameter Selection of Helicobacter pylori Antigens Identifies Two Novel Antigens with High Protective Efficacy

Department of Molecular Biology,¹ Central Unit for Biochemistry, Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany²

Received 1 April 2002/ Returned for modification 28 June 2002/ Accepted 22 July 2002

A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.

Editor: E. I. Tuomanen

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