This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sabarth, N. Articles by Bumann, D. Search for Related Content PubMed PubMed Citation Articles by Sabarth, N. Articles by Bumann, D.

 Previous Article  |  Next Article 

Infection and Immunity, November 2002, p. 6499-6503, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6499-6503.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Multiparameter Selection of Helicobacter pylori Antigens Identifies Two Novel Antigens with High Protective Efficacy

N. Sabarth,¹ R. Hurwitz,² T. F. Meyer,^1* and D. Bumann¹

Department of Molecular Biology,¹ Central Unit for Biochemistry, Max-Planck-Institute for Infection Biology, D-10117 Berlin, Germany²

Received 1 April 2002/ Returned for modification 28 June 2002/ Accepted 22 July 2002

A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.

---

* Corresponding author. Mailing address: Abteilung Molekulare Biologie, Max-Planck-Institut für Infektionsbiologie, Schumannstraße 21/22, D-10117 Berlin, Germany. Phone: 49 30 28460 400. Fax: 49 30 28460 401. E-mail: meyer{at}mpiib-berlin.mpg.de.

Editor: E. I. Tuomanen

---

Infection and Immunity, November 2002, p. 6499-6503, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6499-6503.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

This article has been cited by other articles:

• Gao, L., Weck, M. N., Michel, A., Pawlita, M., Brenner, H. (2009). Association between Chronic Atrophic Gastritis and Serum Antibodies to 15 Helicobacter pylori Proteins Measured by Multiplex Serology. Cancer Res. 69: 2973-2980 [Abstract] [Full Text]  
• Paape, D., Lippuner, C., Schmid, M., Ackermann, R., Barrios-Llerena, M. E., Zimny-Arndt, U., Brinkmann, V., Arndt, B., Pleissner, K. P., Jungblut, P. R., Aebischer, T. (2008). Transgenic, Fluorescent Leishmania mexicana Allow Direct Analysis of the Proteome of Intracellular Amastigotes. Mol. Cell. Proteomics 7: 1688-1701 [Abstract] [Full Text]  
• Aebischer, T, Bumann, D, Epple, H J, Metzger, W, Schneider, T, Cherepnev, G, Walduck, A K, Kunkel, D, Moos, V, Loddenkemper, C, Jiadze, I, Panasyuk, M, Stolte, M, Graham, D Y, Zeitz, M, Meyer, T F (2008). Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines. Gut 57: 1065-1072 [Abstract] [Full Text]  
• Rollenhagen, C., Sorensen, M., Rizos, K., Hurvitz, R., Bumann, D. (2004). Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen. Proc. Natl. Acad. Sci. USA 101: 8739-8744 [Abstract] [Full Text]  
• Krah, A., Schmidt, F., Becher, D., Schmid, M., Albrecht, D., Rack, A., Buttner, K., Jungblut, P. R. (2003). Analysis of Automatically Generated Peptide Mass Fingerprints of Cellular Proteins and Antigens from Helicobacter pylori 26695 Separated by Two-dimensional Electrophoresis. Mol. Cell. Proteomics 2: 1271-1283 [Abstract] [Full Text]