This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wellmer, A.
Right arrow Articles by Nau, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wellmer, A.
Right arrow Articles by Nau, R.

 Previous Article  |  Next Article 

Infection and Immunity, November 2002, p. 6504-6508, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6504-6508.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Decreased Virulence of a Pneumolysin-Deficient Strain of Streptococcus pneumoniae in Murine Meningitis

Andreas Wellmer,1 Gregor Zysk,2 Joachim Gerber,1 Tammo Kunst,1 Matthias von Mering,1 Stefanie Bunkowski,1 Helmut Eiffert,3 and Roland Nau1*

Departments of Neurology,1 Bacteriology, University of Göttingen, Göttingen,3 Institute of Medical Microbiology and Virology, University of Düsseldorf, Düsseldorf, Germany2

Received 8 April 2002/ Returned for modification 5 June 2002/ Accepted 29 July 2002

Pneumolysin, neuraminidases A and B, and hyaluronidase are virulence factors of Streptococcus pneumoniae that appear to be involved in the pathogenesis of meningitis. In a murine model of meningitis after intracerebral infection using mutants of S. pneumoniae D39, only mice infected with a pneumolysin-deficient strain were healthier at 32 and 36 h, had lower bacterial titers in blood at 36 h, and survived longer than the D39 parent strain. Cerebellar and spleen bacterial titers, meningeal inflammation, and neuronal damage scores remained uninfluenced by the lack of any of the virulence factors.

* Corresponding author. Mailing address: Dept. of Neurology, University of Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany. Phone: 49-551-398455. Fax: 49-551-398405. E-mail: rnau{at}gwdg.de.

Editor: V. J. DiRita

Infection and Immunity, November 2002, p. 6504-6508, Vol. 70, No. 11
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.11.6504-6508.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Uchiyama, S., Carlin, A. F., Khosravi, A., Weiman, S., Banerjee, A., Quach, D., Hightower, G., Mitchell, T. J., Doran, K. S., Nizet, V. (2009). The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. JEM 206: 1845-1852 [Abstract] [Full Text]  
  • Chiavolini, D., Pozzi, G., Ricci, S. (2008). Animal Models of Streptococcus pneumoniae Disease. Clin. Microbiol. Rev. 21: 666-685 [Abstract] [Full Text]  
  • Manco, S., Hernon, F., Yesilkaya, H., Paton, J. C., Andrew, P. W., Kadioglu, A. (2006). Pneumococcal Neuraminidases A and B Both Have Essential Roles during Infection of the Respiratory Tract and Sepsis. Infect. Immun. 74: 4014-4020 [Abstract] [Full Text]  
  • Kirkham, L.-A. S., Jefferies, J. M. C., Kerr, A. R., Jing, Y., Clarke, S. C., Smith, A., Mitchell, T. J. (2006). Identification of Invasive Serotype 1 Pneumococcal Isolates That Express Nonhemolytic Pneumolysin. J. Clin. Microbiol. 44: 151-159 [Abstract] [Full Text]  
  • Pracht, D., Elm, C., Gerber, J., Bergmann, S., Rohde, M., Seiler, M., Kim, K. S., Jenkinson, H. F., Nau, R., Hammerschmidt, S. (2005). PavA of Streptococcus pneumoniae Modulates Adherence, Invasion, and Meningeal Inflammation. Infect. Immun. 73: 2680-2689 [Abstract] [Full Text]  
  • Reed, J. M., O'Callaghan, R. J., Girgis, D. O., McCormick, C. C., Caballero, A. R., Marquart, M. E. (2005). Ocular Virulence of Capsule-Deficient Streptococcus pneumoniae in a Rabbit Keratitis Model. IOVS 46: 604-608 [Abstract] [Full Text]  
  • Hirst, R. A., Mohammed, B. J., Mitchell, T. J., Andrew, P. W., O'Callaghan, C. (2004). Streptococcus pneumoniae-Induced Inhibition of Rat Ependymal Cilia Is Attenuated by Antipneumolysin Antibody. Infect. Immun. 72: 6694-6698 [Abstract] [Full Text]  
  • Koedel, U., Rupprecht, T., Angele, B., Heesemann, J., Wagner, H., Pfister, H.-W., Kirschning, C. J. (2004). MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. Brain 127: 1437-1445 [Abstract] [Full Text]  
  • Spreer, A., Kerstan, H., Bottcher, T., Gerber, J., Siemer, A., Zysk, G., Mitchell, T. J., Eiffert, H., Nau, R. (2003). Reduced Release of Pneumolysin by Streptococcus pneumoniae In Vitro and In Vivo after Treatment with Nonbacteriolytic Antibiotics in Comparison to Ceftriaxone. Antimicrob. Agents Chemother. 47: 2649-2654 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»