This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kocyigit, A.
Right arrow Articles by Ulukanligil, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kocyigit, A.
Right arrow Articles by Ulukanligil, M.

 Previous Article  |  Next Article 

Infection and Immunity, December 2002, p. 6589-6591, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.6589-6591.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Antimonial Therapy Induces Circulating Proinflammatory Cytokines in Patients with Cutaneous Leishmaniasis

Abdurrahim Kocyigit,1* Selahaddin Gur,1 Mehmet S. Gurel,2 Vedat Bulut,3 and Mustafa Ulukanligil4

Department of Biochemistry,1 Department of Dermatology,2 Department of Microbiology, University of Harran Medical School, Sanliurfa 63200,4 Department of Immunology, University of Firat Medical School, Elazig 23100, Turkey3

Received 17 May 2002/ Returned for modification 18 July 2002/ Accepted 8 September 2002

The objective of this study was to evaluate the association between antimonial therapy and circulating levels of proinflammatory cytokines in patients with cutaneous leishmaniasis (CL). Patients were treated with conventional chemotherapy by using pentavalent antimonium salts (Glucantime) for 3 weeks. Circulating plasma levels of the proinflammatory cytokines interleukin-1ß (IL-1ß), IL-6, IL-8, and tumor necrosis factor alpha (TNF-{alpha}) were determined for CL patients and healthy subjects before and 3 weeks after the treatment was started. Plasma IL-1ß, IL-6, IL-8, and TNF-{alpha} levels were significantly higher for pretreatment CL patients than for healthy subjects. Proinflammatory cytokines significantly increased after 21 days postinfection compared to levels for the pretreatment patients. These increments were approximately 3-fold for IL-1ß and TNF-{alpha} levels, 10-fold for IL-6 levels, and 20-fold for IL-8 levels in patients with CL. Taken together these results indicate that circulating proinflammatory cytokine levels were increased in patients with CL as a consequence of host defense strategies, and antimonial therapy may induce these cytokines by affecting the macrophage or other components of the host defense system.

* Corresponding author. Mailing address: Harran University School of Medicine, Clinical Biochemistry Department, 63200 Sanliurfa, Turkey. Phone: 90-414 3141170/1128. Fax: 90-414 3151181. E-mail: kocyigit30{at}hotmail.com.

Editor: W. A. Petri, Jr.

Infection and Immunity, December 2002, p. 6589-6591, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.6589-6591.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Murray, H. W. (2008). Accelerated Control of Visceral Leishmania donovani Infection in Interleukin-6-Deficient Mice. Infect. Immun. 76: 4088-4091 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»