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Infection and Immunity, December 2002, p. 6788-6797, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.6788-6797.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Analysis of Salmonella enterica Serotype-Host Specificity in Calves: Avirulence of S. enterica Serotype Gallinarum Correlates with Bacterial Dissemination from Mesenteric Lymph Nodes and Persistence In Vivo

Susan M. Paulin, Patricia R. Watson, Annette R. Benmore, Mark P. Stevens, Philip W. Jones, Bernardo Villarreal-Ramos, and Timothy S. Wallis*

Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom

Received 28 May 2002/ Returned for modification 24 June 2002/ Accepted 27 August 2002

Host and bacterial factors that determine whether Salmonella serotypes remain restricted to the gastrointestinal tract or penetrate beyond the mucosa and cause systemic disease remain largely undefined. Here, factors influencing Salmonella host specificity in calves were assessed by characterizing the pathogenesis of different serotypes. Salmonella enterica serotype Dublin was highly virulent intravenously, whereas S. enterica serotype Choleraesuis was moderately virulent. Both serotypes were virulent in calves infected orally. In contrast, S. enterica serotypes Gallinarum and Abortusovis were avirulent by either route. Serotypes Dublin, Gallinarum, and Abortusovis colonized the intestinal tract 24 h after oral inoculation, yet only serotype Dublin was consistently recovered from systemic tissues. Serotypes Dublin and Gallinarum invaded bovine intestines in greater numbers and induced greater enteropathogenic responses than serotypes Choleraesuis and Abortusovis. However, only serotype Dublin was able to persist within the intestinal mucosa, and use of a novel cannulation model demonstrated that serotype Dublin was able to pass through the mesenteric lymph nodes in greater numbers than serotype Gallinarum. Together, these results suggest that initial interactions with the intestinal mucosa do not correlate with host specificity, although persistence within tissues and translocation via efferent lymphatics appear to be crucial for the induction of bovine salmonellosis.

* Corresponding author. Mailing address: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom. Phone: 44 (0)1635 577230. Fax: 44 (0)1635 577243. E-mail: timothy.wallis{at}bbsrc.ac.uk.

Editor: B. B. Finlay

Infection and Immunity, December 2002, p. 6788-6797, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.6788-6797.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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