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Infection and Immunity, December 2002, p. 7145-7148, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7145-7148.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Generalized Immunological Decline during Long-Term Experimental Infection with Mycobacterium avium

Brad Gilbertson and Christina Cheers*

Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia

Received 25 March 2002/ Returned for modification 21 May 2002/ Accepted 17 September 2002

Terminal loss of immune responsiveness in C57BL/10 mice intranasally infected with Mycobacterium avium was observed in both spleen and lung. It was nonspecific and related to the duration of infection, not the age of the mice. While there was loss of total T cells, the remaining cells were less efficient at gamma interferon production.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia. Phone: 61 3 8344 5708. Fax: 61 3 9347 1540. E-mail: ccheers{at}unimelb.edu.au.

Editor: S. H. E. Kaufmann

Infection and Immunity, December 2002, p. 7145-7148, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7145-7148.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Florido, M., Pearl, J. E., Solache, A., Borges, M., Haynes, L., Cooper, A. M., Appelberg, R. (2005). Gamma Interferon-Induced T-Cell Loss in Virulent Mycobacterium avium Infection. Infect. Immun. 73: 3577-3586 [Abstract] [Full Text]  


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