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Infection and Immunity, December 2002, p. 7169-7171, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7169-7171.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Inhibition of Neisseria gonorrhoeae by Lactobacillus Species That Are Commonly Isolated from the Female Genital Tract

Diane C. St. Amant,{dagger} Iris E. Valentin-Bon,{ddagger} and Ann E. Jerse*

Department of Microbiology and Immunology, F. Edward Hebert School of Medicine, Uniformed Services University, Bethesda, Maryland 20814-4799

Received 26 April 2002/ Returned for modification 20 June 2002/ Accepted 23 August 2002

Epidemiological studies suggest H2O2-producing lactobacilli protect women against gonorrhea. Here we demonstrate that Lactobacillus crispatus and Lactobacillus jensenii, the most common lactobacilli in the female genital tract, inhibit gonococci in both acidic and neutral pH conditions. Inhibition was neutralized by bovine catalase, suggesting that H2O2 is the primary mediator of inhibition.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799. Phone: (301) 295-9629. Fax: (301) 295-3773. E-mail: ajerse{at}usuhs.mil.

Editor: D. L. Burns

{dagger} Present address: SBCCOM, ECBC R&T Dir., AMSSB-RRT-BI, APGEA, Aberdeen, MD 21010.

{ddagger} Present address: FDA, CFSAN, College Park, MD 20740-3835.

Infection and Immunity, December 2002, p. 7169-7171, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7169-7171.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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