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Infection and Immunity, December 2002, p. 7176-7178, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7176-7178.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Peptidoglycan N-Acetylglucosamine Deacetylase, a Putative Virulence Factor in Streptococcus pneumoniae

Waldemar Vollmer{dagger} and Alexander Tomasz*

Laboratory of Microbiology, The Rockefeller University, New York, New York 10021

Received 19 June 2002/ Returned for modification 7 August 2002/ Accepted 28 August 2002

Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

* Corresponding author. Mailing address: The Rockefeller University, Laboratory of Microbiology, 1230 York Ave., New York, N.Y. 10021. Phone: (212) 327-8278. Fax: (212) 327-8688. E-mail: tomasz{at}mail.rockefeller.edu.

Editor: J. T. Barbieri

{dagger} Present address: Max-Planck-Institut für Entwicklungsbiologie, Abteilung Biochemie, 72076 Tübingen, Germany.

Infection and Immunity, December 2002, p. 7176-7178, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7176-7178.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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