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Infection and Immunity, December 2002, p. 7179-7181, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7179-7181.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Expression of NADPH Oxidase-Dependent Resistance to Listeriosis in Mice Occurs during the First 6 to 12 Hours of Liver Infection

Ronald LaCourse, Lynn Ryan, and Robert J. North*

The Trudeau Institute, Saranac Lake, New York 12983

Received 21 June 2002/ Returned for modification 19 August 2002/ Accepted 19 September 2002

Wild-type mice inoculated with Listeria monocytogenes intravenously were capable of reducing the bacterial load in their livers by 90% within 6 h. In contrast, mice with deletions of the gene for NADPH oxidase were incapable of expressing this early oxygen-dependent anti-Listeria defense and consequently showed higher levels of liver infection at later times.

* Corresponding author. Mailing address: The Trudeau Institute, 100 Algonquin Ave., Saranac Lake, NY 12983. Phone: (518) 891-3080. Fax: (518) 891-5126. E-mail: rjnorth{at}northnet.org.

Editor: B. B. Finlay

Infection and Immunity, December 2002, p. 7179-7181, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7179-7181.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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