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Infection and Immunity, December 2002, p. 7182-7184, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7182-7184.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Plasmodium falciparum Serine Repeat Protein, a New Target of Monocyte-Dependent Antibody-Mediated Parasite Killing

Soe Soe,1 Subhash Singh,1 Daniel Camus,2 Toshihiro Horii,3 and Pierre Druilhe1*

BioMedical Parasitology Unit, Pasteur Institute, 75015 Paris,1 Department of Parasitology, Faculté de Médecine, Lille, France,2 Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita Osaka 565, Japan3

Received 3 December 2001/ Returned for modification 13 February 2002/ Accepted 28 August 2002

Using monoclonal antibodies and human affinity-purified antibodies specific to the Plasmodium falciparum 126-kDa serine-rich protein, SERP, we found that these antibodies have no direct effect upon merozoite invasion at the concentrations tested but can cooperate with blood monocytes to strongly inhibit P. falciparum in vitro growth.

* Corresponding author. Mailing address: Unité de Parasitologie Bio-Médicale, Institut Pasteur, 25 Rue du Dr Roux, 75015 Paris, France. Phone: 331 45 68 85 78. Fax: 331 45 68 86 40. E-mail: druilhe{at}pasteur.fr.

Editor: J. M. Mansfield

Infection and Immunity, December 2002, p. 7182-7184, Vol. 70, No. 12
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.12.7182-7184.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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