This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Loucká, J. Articles by Sebo, P. Search for Related Content PubMed PubMed Citation Articles by Loucká, J. Articles by Sebo, P.

 Previous Article  |  Next Article 

Infection and Immunity, February 2002, p. 1002-1005, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1002-1005.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Delivery of a MalE CD4⁺-T-Cell Epitope into the Major Histocompatibility Complex Class II Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase

Jiina Loucká,¹ Géraldine Schlecht,² Jana Vodolánová,¹ Claude Leclerc,² Peter ebo,^1*

Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Academy of Sciences of the Czech Republic, CZ-142 20 Prague 4, Czech Republic,¹ Unité de Biologie des Régulations Immunitaires, Institut Pasteur, 75724 Paris, France²

Received 20 June 2001/ Returned for modification 7 August 2001/ Accepted 6 November 2001

Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4⁺-T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4⁺-T-cell response in vivo and yielding in vitro stimulation of specific CD4⁺ T cells at a 100-times-higher molar efficiency than the free peptide containing the epitope.

Editor: J. D. Clements

This article has been cited by other articles:

• Connell, T. G., Shey, M. S., Seldon, R., Rangaka, M. X., van Cutsem, G., Simsova, M., Marcekova, Z., Sebo, P., Curtis, N., Diwakar, L., Meintjes, G. A., Leclerc, C., Wilkinson, R. J., Wilkinson, K. A. (2007). Enhanced Ex Vivo Stimulation of Mycobacterium tuberculosis-Specific T Cells in Human Immunodeficiency Virus-Infected Persons via Antigen Delivery by the Bordetella pertussis Adenylate Cyclase Vector. CVI 14: 847-854 [Abstract] [Full Text]  
• Hervas-Stubbs, S., Majlessi, L., Simsova, M., Morova, J., Rojas, M.-J., Nouze, C., Brodin, P., Sebo, P., Leclerc, C. (2006). High Frequency of CD4+ T Cells Specific for the TB10.4 Protein Correlates with Protection against Mycobacterium tuberculosis Infection.. Infect. Immun. 74: 3396-3407 [Abstract] [Full Text]  
• Majlessi, L., Simsova, M., Jarvis, Z., Brodin, P., Rojas, M.-J., Bauche, C., Nouze, C., Ladant, D., Cole, S. T., Sebo, P., Leclerc, C. (2006). An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis. Infect. Immun. 74: 2128-2137 [Abstract] [Full Text]  
• Tartz, S., Kamanova, J., Simsova, M., Sebo, P., Bolte, S., Heussler, V., Fleischer, B., Jacobs, T. (2006). Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria. Infect. Immun. 74: 2277-2285 [Abstract] [Full Text]  
• Mascarell, L., Fayolle, C., Bauche, C., Ladant, D., Leclerc, C. (2005). Induction of Neutralizing Antibodies and Th1-Polarized and CD4-Independent CD8+ T-Cell Responses following Delivery of Human Immunodeficiency Virus Type 1 Tat Protein by Recombinant Adenylate Cyclase of Bordetella pertussis. J. Virol. 79: 9872-9884 [Abstract] [Full Text]  
• Wilkinson, K. A., Simsova, M., Scholvinck, E., Sebo, P., Leclerc, C., Vordermeier, H. M., Dickson, S. J., Brown, J. R., Davidson, R. N., Pasvol, G., Levin, M., Wilkinson, R. J. (2005). Efficient Ex Vivo Stimulation of Mycobacterium tuberculosis-Specific T Cells by Genetically Detoxified Bordetella pertussis Adenylate Cyclase Antigen Toxoids. Infect. Immun. 73: 2991-2998 [Abstract] [Full Text]  
• Schlecht, G., Loucka, J., Najar, H., Sebo, P., Leclerc, C. (2004). Antigen Targeting to CD11b Allows Efficient Presentation of CD4+ and CD8+ T Cell Epitopes and In Vivo Th1-Polarized T Cell Priming. J. Immunol. 173: 6089-6097 [Abstract] [Full Text]  
• Vordermeier, H. M., Simsova, M., Wilkinson, K. A., Wilkinson, R. J., Hewinson, R. G., Sebo, P., Leclerc, C. (2004). Recognition of Mycobacterial Antigens Delivered by Genetically Detoxified Bordetella pertussis Adenylate Cyclase by T Cells from Cattle with Bovine Tuberculosis. Infect. Immun. 72: 6255-6261 [Abstract] [Full Text]  
• Ross, P. J., Lavelle, E. C., Mills, K. H. G., Boyd, A. P. (2004). Adenylate Cyclase Toxin from Bordetella pertussis Synergizes with Lipopolysaccharide To Promote Innate Interleukin-10 Production and Enhances the Induction of Th2 and Regulatory T Cells. Infect. Immun. 72: 1568-1579 [Abstract] [Full Text]  
• Dadaglio, G., Morel, S., Bauche, C., Moukrim, Z., Lemonnier, F. A., Van den Eynde, B. J., Ladant, D., Leclerc, C. (2003). Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes. Int Immunol 15: 1423-1430 [Abstract] [Full Text]