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Infection and Immunity, February 2002, p. 1002-1005, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1002-1005.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Delivery of a MalE CD4+-T-Cell Epitope into the Major Histocompatibility Complex Class II Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase

Jiina Loucká,1 Géraldine Schlecht,2 Jana Vodolánová,1 Claude Leclerc,2 Peter ebo,1*

Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Academy of Sciences of the Czech Republic, CZ-142 20 Prague 4, Czech Republic,1 Unité de Biologie des Régulations Immunitaires, Institut Pasteur, 75724 Paris, France2

Received 20 June 2001/ Returned for modification 7 August 2001/ Accepted 6 November 2001

Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4+-T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4+-T-cell response in vivo and yielding in vitro stimulation of specific CD4+ T cells at a 100-times-higher molar efficiency than the free peptide containing the epitope.

* Corresponding author. Mailing address: Institute of Microbiology CAS, Vídeská 1083, CZ-142 20 Prague 4, Czech Republic. Phone: (4202) 475 2762. Fax: (4202) 475 2152. E-mail: sebo{at}0040biomed.cas.cz.

Editor: J. D. Clements

Infection and Immunity, February 2002, p. 1002-1005, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1002-1005.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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