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Infection and Immunity, February 2002, p. 1023-1026, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1023-1026.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Leishmania major Promastigotes Inhibit Dendritic Cell Motility In Vitro

Heather Jebbari,1* Andrew J. Stagg,1 Robert N. Davidson,2 and Stella C. Knight1

Antigen Presentation Research Group, Department of Immunology,1 Department of Infectious Diseases and Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom2

Received 25 April 2001/ Returned for modification 4 June 2001/ Accepted 12 November 2001

Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.

* Corresponding author. Mailing address: Mycobacterium Reference Unit, Dulwich Public Health Laboratory, Dulwich Hospital, East Dulwich Grove, London SE22 8QF, United Kingdom. Phone: 020 8693 1312. Fax: 020 7436 6477. E-mail: hjebbari{at}yahoo.co.uk.

Editor: J. M. Mansfield

Infection and Immunity, February 2002, p. 1023-1026, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1023-1026.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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