This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jebbari, H.
Right arrow Articles by Knight, S. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jebbari, H.
Right arrow Articles by Knight, S. C.

 Previous Article  |  Next Article 

Infection and Immunity, February 2002, p. 1023-1026, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1023-1026.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Leishmania major Promastigotes Inhibit Dendritic Cell Motility In Vitro

Heather Jebbari,1* Andrew J. Stagg,1 Robert N. Davidson,2 and Stella C. Knight1

Antigen Presentation Research Group, Department of Immunology,1 Department of Infectious Diseases and Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom2

Received 25 April 2001/ Returned for modification 4 June 2001/ Accepted 12 November 2001

Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.

* Corresponding author. Mailing address: Mycobacterium Reference Unit, Dulwich Public Health Laboratory, Dulwich Hospital, East Dulwich Grove, London SE22 8QF, United Kingdom. Phone: 020 8693 1312. Fax: 020 7436 6477. E-mail: hjebbari{at}yahoo.co.uk.

Editor: J. M. Mansfield

Infection and Immunity, February 2002, p. 1023-1026, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.1023-1026.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Colmenares, M., Corbi, A. L., Turco, S. J., Rivas, L. (2004). The Dendritic Cell Receptor DC-SIGN Discriminates among Species and Life Cycle Forms of Leishmania. J. Immunol. 172: 1186-1190 [Abstract] [Full Text]  
  • Rotta, G., Edwards, E. W., Sangaletti, S., Bennett, C., Ronzoni, S., Colombo, M. P., Steinman, R. M., Randolph, G. J., Rescigno, M. (2003). Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo. JEM 198: 1253-1263 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»