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Infection and Immunity, February 2002, p. 679-684, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.679-684.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Investigation of Role of Nitric Oxide in Protection from Bordetella pertussis Respiratory Challenge

C. Canthaboo,1 D. Xing,1* X. Q. Wei,2 and M. J. Corbel1

Division of Bacteriology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG,1 Department of Immunology and Bacteriology, University of Glasgow, Glasgow G11 6NT, United Kingdom2

Received 22 August 2001/ Returned for modification 20 September 2001/ Accepted 6 November 2001

The mechanism whereby whole-cell pertussis vaccines (WCV) confer protection against Bordetella pertussis is still not fully understood. We have previously reported that macrophage activation produced by vaccination with WCV is associated with induction of NO synthesis by macrophages in response to in vitro stimulation with B. pertussis antigens. To determine whether NO production is an effector of protection or simply a marker of activation, the susceptibility of inducible nitric oxide synthase (type II, iNOS) knockout mice to infection with B. pertussis was examined. We showed that iNOS knockout mice were more susceptible to B. pertussis respiratory challenge than wild-type mice. iNOS-deficient mice also developed a less effective protective response than wild-type mice after the same immunization with WCV. This suggests that NO plays an important role in effecting protection against B. pertussis challenge.

* Corresponding author. Mailing address: Division of Bacteriology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom. Phone: (44) 01707-654753. Fax: (44) 01707-663796. E-mail: dxing{at}nibsc.ac.uk.

Editor: J. D. Clements

Infection and Immunity, February 2002, p. 679-684, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.679-684.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cheung, G. Y. C., Xing, D., Prior, S., Corbel, M. J., Parton, R., Coote, J. G. (2006). Effect of Different Forms of Adenylate Cyclase Toxin of Bordetella pertussis on Protection Afforded by an Acellular Pertussis Vaccine in a Murine Model. Infect. Immun. 74: 6797-6805 [Abstract] [Full Text]  
  • Higgins, S. C., Jarnicki, A. G., Lavelle, E. C., Mills, K. H. G. (2006). TLR4 Mediates Vaccine-Induced Protective Cellular Immunity to Bordetella pertussis: Role of IL-17-Producing T Cells. J. Immunol. 177: 7980-7989 [Abstract] [Full Text]  


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