This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Farah, C. S.
Right arrow Articles by Ashman, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Farah, C. S.
Right arrow Articles by Ashman, R. B.

 Previous Article  |  Next Article 

Infection and Immunity, February 2002, p. 724-731, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.724-731.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Primary Role for CD4+ T Lymphocytes in Recovery from Oropharyngeal Candidiasis

C. S. Farah,1* S. Elahi,2 K. Drysdale,1 G. Pang,2 T. Gotjamanos,3 G. J. Seymour,1 R. L. Clancy,2 and R. B. Ashman1

Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, Queensland 4072,1 Discipline of ImmunologyMicrobiology, University of Newcastle, Newcastle, New South Wales 2300,,2 Department of Pathology, QEII Medical Centre, University of Western Australia, Nedlands, Western Australia 6907, Australia3

Received 23 July 2001/ Returned for modification 9 August 2001/ Accepted 8 November 2001

Oropharyngeal candidiasis is associated with defects in cell-mediated immunity and is commonly seen in human immunodeficiency virus positive individuals and AIDS patients. A model for oral candidiasis in T-cell-deficient BALB/c and CBA/CaH nu/nu mice was established. After inoculation with 108 Candida albicans yeasts, these mice displayed increased levels of oral colonization compared to euthymic control mice and developed a chronic oropharyngeal infection. Histopathological examination of nu/nu oral tissues revealed extensive hyphae penetrating the epithelium, with polymorphonuclear leukocyte microabscess formation. Adoptive transfer of either naive or immune lymphocytes into immunodeficient mice resulted in the recovery of these animals from the oral infection. Reconstitution of immunodeficient mice with naive CD4+ but not CD8+ T cells significantly decreased oral colonization compared to controls. Interleukin-12 and gamma interferon were detected in the draining lymph nodes of immunodeficient mice following reconstitution with naive lymphocytes. This study demonstrates the direct requirement for T lymphocytes in recovery from oral candidiasis and suggests that this is associated with the production of cytokines by CD4+ T helper cells.

* Corresponding author. Mailing address: Oral Biology and Pathology, The University of Queensland, Brisbane, QLD 4072, Australia. Phone: 61 7 3365 8840. Fax: 61 7 3365 1109. E-mail: c.farah{at}uq.edu.au.

Editor: T. R. Kozel

Infection and Immunity, February 2002, p. 724-731, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.724-731.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Goupil, M., Trudelle, E. B., Dugas, V., Racicot-Bergeron, C., Aumont, F., Senechal, S., Hanna, Z., Jolicoeur, P., de Repentigny, L. (2009). Macrophage-Mediated Responses to Candida albicans in Mice Expressing the Human Immunodeficiency Virus Type 1 Transgene. Infect. Immun. 77: 4136-4149 [Abstract] [Full Text]  
  • Hubert, F.-X., Kinkel, S. A., Crewther, P. E., Cannon, P. Z. F., Webster, K. E., Link, M., Uibo, R., O'Bryan, M. K., Meager, A., Forehan, S. P., Smyth, G. K., Mittaz, L., Antonarakis, S. E., Peterson, P., Heath, W. R., Scott, H. S. (2009). Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype. J. Immunol. 182: 3902-3918 [Abstract] [Full Text]  
  • Pirofski, L.-a., Casadevall, A. (2009). Rethinking T cell immunity in oropharyngeal candidiasis. JEM 206: 269-273 [Abstract] [Full Text]  
  • Lewandowski, D., Marquis, M., Aumont, F., Lussier-Morin, A.-C., Raymond, M., Senechal, S., Hanna, Z., Jolicoeur, P., de Repentigny, L. (2006). Altered CD4+ T Cell Phenotype and Function Determine the Susceptibility to Mucosal Candidiasis in Transgenic Mice Expressing HIV-1. J. Immunol. 177: 479-491 [Abstract] [Full Text]  
  • Marquis, M., Lewandowski, D., Dugas, V., Aumont, F., Senechal, S., Jolicoeur, P., Hanna, Z., de Repentigny, L. (2006). CD8+ T Cells but Not Polymorphonuclear Leukocytes Are Required To Limit Chronic Oral Carriage of Candida albicans in Transgenic Mice Expressing Human Immunodeficiency Virus Type 1. Infect. Immun. 74: 2382-2391 [Abstract] [Full Text]  
  • Dongari-Bagtzoglou, A., Fidel, P.L. Jr. (2005). The Host Cytokine Responses and Protective Immunity in Oropharyngeal Candidiasis. JDR 84: 966-977 [Abstract] [Full Text]  
  • McNulty, K. M., Plianrungsi, J., Leigh, J. E., Mercante, D., Fidel, P. L. Jr. (2005). Characterization of CD8+ T Cells and Microenvironment in Oral Lesions of Human Immunodeficiency Virus-Infected Persons with Oropharyngeal Candidiasis. Infect. Immun. 73: 3659-3667 [Abstract] [Full Text]  
  • de Repentigny, L., Lewandowski, D., Jolicoeur, P. (2004). Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection. Clin. Microbiol. Rev. 17: 729-759 [Abstract] [Full Text]  
  • Tavanti, A., Pardini, G., Campa, D., Davini, P., Lupetti, A., Senesi, S. (2004). Differential Expression of Secretory Aspartyl Proteinase Genes (SAP1-10) in Oral Candida albicans Isolates with Distinct Karyotypes. J. Clin. Microbiol. 42: 4726-4734 [Abstract] [Full Text]  
  • Santoni, G., Boccanera, M., Adriani, D., Lucciarini, R., Amantini, C., Morrone, S., Cassone, A., De Bernardis, F. (2002). Immune Cell-Mediated Protection against Vaginal Candidiasis: Evidence for a Major Role of Vaginal CD4+ T Cells and Possible Participation of Other Local Lymphocyte Effectors. Infect. Immun. 70: 4791-4797 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»