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Infection and Immunity, February 2002, p. 970-973, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.2.970-973.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Dominant-Negative Rho, Rac, and Cdc42 Facilitate the Invasion Process of Vibrio parahaemolyticus into Caco-2 Cells

Yukihiro Akeda,1* Toshio Kodama,1 Takashige Kashimoto,2,3 Vlademir Cantarelli,1 Yasuhiko Horiguchi,2 Kenichi Nagayama,1 Tetsuya Iida,1 and Takeshi Honda1

Department of Bacterial Infections,1 Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871,2 Department of Veterinary Public Health, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori 034-8626, Japan3

Received 9 July 2001/ Returned for modification 28 August 2001/ Accepted 23 October 2001

To clarify the invasive process of Vibrio parahaemolyticus, an invasion assay was performed using cells expressing dominant negative small GTPases of the Rho family. This assay showed that the dominant negative host phenotype facilitates bacterial invasion, suggesting that the mechanism of V. parahaemolyticus invasion differs from that reported for other invasive bacteria.

* Corresponding author. Mailing address: Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan. Phone: 81-6-6879-8278. Fax: 81-6-6879-8277. E-mail: yukihiro{at}biken.osaka-u.ac.jp.

Editor: D. L. Burns

Infection and Immunity, February 2002, p. 970-973, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 10.1128/IAI.70.2.970-973.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Trosky, J. E., Mukherjee, S., Burdette, D. L., Roberts, M., McCarter, L., Siegel, R. M., Orth, K. (2004). Inhibition of MAPK Signaling Pathways by VopA from Vibrio parahaemolyticus. J. Biol. Chem. 279: 51953-51957 [Abstract] [Full Text]  


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