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Infection and Immunity, February 2002, p. 993-997, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.993-997.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Novel Laminin-Binding Protein of Streptococcus pyogenes, Lbp, Is Involved in Adhesion to Epithelial Cells

Yutaka Terao, Shigetada Kawabata,* Eiji Kunitomo, Ichiro Nakagawa, and Shigeyuki Hamada

Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita-Osaka 565-0871, Japan

Received 26 July 2001/ Returned for modification 25 August 2001/ Accepted 8 November 2001

The lbp gene, which encodes a laminin-binding protein (Lbp) of Streptococcus pyogenes, was found in all S. pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins.

* Corresponding author. Mailing address: Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1-8, Yamadaoka, Suita-Osaka 565-0871, Japan. Phone: 81-6-6879-2898. Fax: 81-6-6878-4755. E-mail: kawabata{at}0040dent.osaka-u.ac.jp.

Editor: E. I. Tuomanen

Infection and Immunity, February 2002, p. 993-997, Vol. 70, No. 2
0019-9567/01/$04.00+0     DOI: 70.2.993-997.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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