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Infection and Immunity, March 2002, p. 1202-1208, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1202-1208.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Structure of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity and Clinical Features of Guillain-Barré and Miller Fisher Patients

C. W. Ang,1,2,3* J. D. Laman,1 H. J. Willison,4 E. R. Wagner,4 H. P. Endtz,3 M. A. De Klerk,1,2 A. P. Tio-Gillen,1,2 N. Van den Braak,3 B. C. Jacobs,1,2 and P. A. Van Doorn1

Departments of Neurology,1 Immunology,2 Microbiology and Infectious Diseases, Erasmus University/Academic Hospital Dijkzigt Rotterdam, Rotterdam, The Netherlands,3 Department of Neurology, Southern General Hospital, Glasgow G51 4TF, Scotland4

Received 22 August 2001/ Returned for modification 5 November 2001/ Accepted 21 November 2001

Ganglioside mimicry in the lipopolysaccharide (LPS) fraction of Campylobacter jejuni isolated from Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) patients was compared with isolates from patients with an uncomplicated enteritis. The antibody response to C. jejuni LPS and gangliosides in neuropathy patients and controls was compared as well. LPS from GBS and MFS-associated isolates more frequently contained ganglioside-like epitopes compared to control isolates. Almost all neuropathy patients showed a strong antibody response against LPS and multiple gangliosides in contrast to enteritis patients. Isolates from GBS patients more frequently had a GM1-like epitope than isolates from MFS patients. GQ1b-like epitopes were present in all MFS-associated isolates and was associated with anti-GQ1b antibody reactivity and the presence of oculomotor symptoms. These results demonstrate that the expression of ganglioside mimics is a risk factor for the development of post-Campylobacter neuropathy. This study provides additional evidence for the hypothesis that the LPS fraction determines the antiganglioside specificity and clinical features in post-Campylobacter neuropathy patients.

* Corresponding author. Mailing address: Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. Phone: 31-10-463-3867. Fax: 31-10-463-3857. E-mail: Ang{at}bacl.azr.nl.

Infection and Immunity, March 2002, p. 1202-1208, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1202-1208.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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