This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kerr, A. R.
Right arrow Articles by Mitchell, Tim. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kerr, A. R.
Right arrow Articles by Mitchell, Tim. J.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH

 Previous Article  |  Next Article 

Infection and Immunity, March 2002, p. 1547-1557, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1547-1557.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of Inflammatory Mediators in Resistance and Susceptibility to Pneumococcal Infection

Alison R. Kerr,1 June J. Irvine,1 Jennifer J. Search,1 Neill A. Gingles,2 Aras Kadioglu,2 Peter W. Andrew,2 William L. McPheat,3 Charles G. Booth,3 and Tim. J. Mitchell1*

Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ,1 Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN,2 AstraZeneca, Discovery Research, Mereside, Alderley Edge, Cheshire SK10 4TG, United Kingdom3

Received 13 September 2001/ Returned for modification 12 November 2001/ Accepted 12 December 2001

Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia.

* Corresponding author. Mailing address: Division of Infection and Immunity, IBLS, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom. Phone: 44 141 330 3749. Fax: 44 141 330 3727. E-mail: T.Mitchell{at}bio.gla.ac.uk.

Infection and Immunity, March 2002, p. 1547-1557, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1547-1557.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ferreira, D. M., Darrieux, M., Silva, D. A., Leite, L. C. C., Ferreira, J. M. C. Jr., Ho, P. L., Miyaji, E. N., Oliveira, M. L. S. (2009). Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice. CVI 16: 636-645 [Abstract] [Full Text]  
  • Miyazaki, S., Ishikawa, F., Matsuo, S., Yamaguchi, K. (2008). Effect of fluoroquinolones on body temperature of mice. J Antimicrob Chemother 62: 1319-1322 [Abstract] [Full Text]  
  • Xu, F., Droemann, D., Rupp, J., Shen, H., Wu, X., Goldmann, T., Hippenstiel, S., Zabel, P., Dalhoff, K. (2008). Modulation of the Inflammatory Response to Streptococcus pneumoniae in a Model of Acute Lung Tissue Infection. Am. J. Respir. Cell Mol. Bio. 39: 522-529 [Abstract] [Full Text]  
  • Chiavolini, D., Pozzi, G., Ricci, S. (2008). Animal Models of Streptococcus pneumoniae Disease. Clin. Microbiol. Rev. 21: 666-685 [Abstract] [Full Text]  
  • Kafka, D., Ling, E., Feldman, G., Benharroch, D., Voronov, E., Givon-Lavi, N., Iwakura, Y., Dagan, R., Apte, R. N., Mizrachi-Nebenzahl, Y. (2008). Contribution of IL-1 to resistance to Streptococcus pneumoniae infection. Int Immunol 20: 1139-1146 [Abstract] [Full Text]  
  • Calbo, E., Alsina, M., Rodriguez-Carballeira, M., Lite, J., Garau, J. (2008). Systemic Expression of Cytokine Production in Patients with Severe Pneumococcal Pneumonia: Effects of Treatment with a {beta}-Lactam versus a Fluoroquinolone. Antimicrob. Agents Chemother. 52: 2395-2402 [Abstract] [Full Text]  
  • Hendriksen, W. T., Kloosterman, T. G., Bootsma, H. J., Estevao, S., de Groot, R., Kuipers, O. P., Hermans, P. W. M. (2008). Site-Specific Contributions of Glutamine-Dependent Regulator GlnR and GlnR-Regulated Genes to Virulence of Streptococcus pneumoniae. Infect. Immun. 76: 1230-1238 [Abstract] [Full Text]  
  • Ferreira, D. M., Darrieux, M., Oliveira, M. L. S., Leite, L. C. C., Miyaji, E. N. (2008). Optimized Immune Response Elicited by a DNA Vaccine Expressing Pneumococcal Surface Protein A Is Characterized by a Balanced Immunoglobulin G1 (IgG1)/IgG2a Ratio and Proinflammatory Cytokine Production. CVI 15: 499-505 [Abstract] [Full Text]  
  • Mahdi, L. K., Ogunniyi, A. D., LeMessurier, K. S., Paton, J. C. (2008). Pneumococcal Virulence Gene Expression and Host Cytokine Profiles during Pathogenesis of Invasive Disease. Infect. Immun. 76: 646-657 [Abstract] [Full Text]  
  • Hendriksen, W. T., Bootsma, H. J., Estevao, S., Hoogenboezem, T., de Jong, A., de Groot, R., Kuipers, O. P., Hermans, P. W. M. (2008). CodY of Streptococcus pneumoniae: Link between Nutritional Gene Regulation and Colonization. J. Bacteriol. 190: 590-601 [Abstract] [Full Text]  
  • Gauthier, J.-F., Fortin, A., Bergeron, Y., Dumas, M.-C., Champagne, M.-E., Bergeron, M. G. (2007). Differential Contribution of Bacterial N-Formyl-Methionyl-Leucyl- Phenylalanine and Host-Derived CXC Chemokines to Neutrophil Infiltration into Pulmonary Alveoli during Murine Pneumococcal Pneumonia. Infect. Immun. 75: 5361-5367 [Abstract] [Full Text]  
  • Wang, X., Meng, X., Kuhlman, J. R., Nelin, L. D., Nicol, K. K., English, B. K., Liu, Y. (2007). Knockout of Mkp-1 Enhances the Host Inflammatory Responses to Gram-Positive Bacteria. J. Immunol. 178: 5312-5320 [Abstract] [Full Text]  
  • Hendriksen, W. T., Silva, N., Bootsma, H. J., Blue, C. E., Paterson, G. K., Kerr, A. R., de Jong, A., Kuipers, O. P., Hermans, P. W. M., Mitchell, T. J. (2007). Regulation of Gene Expression in Streptococcus pneumoniae by Response Regulator 09 Is Strain Dependent. J. Bacteriol. 189: 1382-1389 [Abstract] [Full Text]  
  • Graham, R. M. A., Paton, J. C. (2006). Differential Role of CbpA and PspA in Modulation of In Vitro CXC Chemokine Responses of Respiratory Epithelial Cells to Infection with Streptococcus pneumoniae. Infect. Immun. 74: 6739-6749 [Abstract] [Full Text]  
  • Vorderstrasse, B. A., Lawrence, B. P. (2006). Protection against Lethal Challenge with Streptococcus pneumoniae Is Conferred by Aryl Hydrocarbon Receptor Activation but Is Not Associated with an Enhanced Inflammatory Response.. Infect. Immun. 74: 5679-5686 [Abstract] [Full Text]  
  • Zhang, Q., Bernatoniene, J., Bagrade, L., Paton, J. C., Mitchell, T. J., Hammerschmidt, S., Nunez, D. A., Finn, A. (2006). Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children.. Infect. Immun. 74: 4735-4743 [Abstract] [Full Text]  
  • Mold, C., Du Clos, T. W. (2006). C-Reactive Protein Increases Cytokine Responses to Streptococcus pneumoniae through Interactions with Fc{gamma} Receptors.. J. Immunol. 176: 7598-7604 [Abstract] [Full Text]  
  • Hermans, P. W. M., Adrian, P. V., Albert, C., Estevao, S., Hoogenboezem, T., Luijendijk, I. H. T., Kamphausen, T., Hammerschmidt, S. (2006). The Streptococcal Lipoprotein Rotamase A (SlrA) Is a Functional Peptidyl-prolyl Isomerase Involved in Pneumococcal Colonization. J. Biol. Chem. 281: 968-976 [Abstract] [Full Text]  
  • Kirkham, L.-A. S., Kerr, A. R., Douce, G. R., Paterson, G. K., Dilts, D. A., Liu, D.-F., Mitchell, T. J. (2006). Construction and Immunological Characterization of a Novel Nontoxic Protective Pneumolysin Mutant for Use in Future Pneumococcal Vaccines. Infect. Immun. 74: 586-593 [Abstract] [Full Text]  
  • Kirkham, L.-A. S., Jefferies, J. M. C., Kerr, A. R., Jing, Y., Clarke, S. C., Smith, A., Mitchell, T. J. (2006). Identification of Invasive Serotype 1 Pneumococcal Isolates That Express Nonhemolytic Pneumolysin. J. Clin. Microbiol. 44: 151-159 [Abstract] [Full Text]  
  • Burns, T., Abadi, M., Pirofski, L.-a. (2005). Modulation of the Lung Inflammatory Response to Serotype 8 Pneumococcal Infection by a Human Immunoglobulin M Monoclonal Antibody to Serotype 8 Capsular Polysaccharide. Infect. Immun. 73: 4530-4538 [Abstract] [Full Text]  
  • Kerr, A. R., Paterson, G. K., Riboldi-Tunnicliffe, A., Mitchell, T. J. (2005). Innate Immune Defense against Pneumococcal Pneumonia Requires Pulmonary Complement Component C3. Infect. Immun. 73: 4245-4252 [Abstract] [Full Text]  
  • Paterson, G K, Blue, C E, Mitchell, T J (2005). Role of interleukin-18 in experimental infections with Streptococcus pneumoniae. J Med Microbiol 54: 323-326 [Abstract] [Full Text]  
  • Ibrahim, Y. M., Kerr, A. R., Silva, N. A., Mitchell, T. J. (2005). Contribution of the ATP-Dependent Protease ClpCP to the Autolysis and Virulence of Streptococcus pneumoniae. Infect. Immun. 73: 730-740 [Abstract] [Full Text]  
  • Giles, J. T., Bathon, J. M. (2004). Serious Infections Associated with Anticytokine Therapies in the Rheumatic Diseases. J Intensive Care Med 19: 320-334 [Abstract]  
  • Bast, D. J., Yue, M., Chen, X., Bell, D., Dresser, L., Saskin, R., Mandell, L. A., Low, D. E., de Azavedo, J. C. S. (2004). Novel Murine Model of Pneumococcal Pneumonia: Use of Temperature as a Measure of Disease Severity To Compare the Efficacies of Moxifloxacin and Levofloxacin. Antimicrob. Agents Chemother. 48: 3343-3348 [Abstract] [Full Text]  
  • Ibrahim, Y. M., Kerr, A. R., McCluskey, J., Mitchell, T. J. (2004). Control of Virulence by the Two-Component System CiaR/H Is Mediated via HtrA, a Major Virulence Factor of Streptococcus pneumoniae. J. Bacteriol. 186: 5258-5266 [Abstract] [Full Text]  
  • Kerr, A. R., Adrian, P. V., Estevao, S., de Groot, R., Alloing, G., Claverys, J.-P., Mitchell, T. J., Hermans, P. W. M. (2004). The Ami-AliA/AliB Permease of Streptococcus pneumoniae Is Involved in Nasopharyngeal Colonization but Not in Invasive Disease. Infect. Immun. 72: 3902-3906 [Abstract] [Full Text]  
  • Ibrahim, Y. M., Kerr, A. R., McCluskey, J., Mitchell, T. J. (2004). Role of HtrA in the Virulence and Competence of Streptococcus pneumoniae. Infect. Immun. 72: 3584-3591 [Abstract] [Full Text]  
  • Preston, J.A., Beagley, K.W., Gibson, P.G., Hansbro, P.M. (2004). Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia. Eur Respir J 23: 224-231 [Abstract] [Full Text]  
  • Dockrell, D. H., Marriott, H. M., Prince, L. R., Ridger, V. C., Ince, P. G., Hellewell, P. G., Whyte, M. K. B. (2003). Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection. J. Immunol. 171: 5380-5388 [Abstract] [Full Text]  
  • Blue, C. E., Paterson, G. K., Kerr, A. R., Berge, M., Claverys, J. P., Mitchell, T. J. (2003). ZmpB, a Novel Virulence Factor of Streptococcus pneumoniae That Induces Tumor Necrosis Factor Alpha Production in the Respiratory Tract. Infect. Immun. 71: 4925-4935 [Abstract] [Full Text]  
  • Jounblat, R., Kadioglu, A., Mitchell, T. J., Andrew, P. W. (2003). Pneumococcal Behavior and Host Responses during Bronchopneumonia Are Affected Differently by the Cytolytic and Complement-Activating Activities of Pneumolysin. Infect. Immun. 71: 1813-1819 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»