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Infection and Immunity, March 2002, p. 1547-1557, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1547-1557.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of Inflammatory Mediators in Resistance and Susceptibility to Pneumococcal Infection

Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ,¹ Department of Microbiology and Immunology, University of Leicester, Leicester LE1 9HN,² AstraZeneca, Discovery Research, Mereside, Alderley Edge, Cheshire SK10 4TG, United Kingdom³

Received 13 September 2001/ Returned for modification 12 November 2001/ Accepted 12 December 2001

Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia.

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