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Infection and Immunity, March 2002, p. 1609-1614, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1609-1614.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

HLA-B27-Transfected (Salmonella Permissive) and HLA-A2-Transfected (Salmonella Nonpermissive) Human Monocytic U937 Cells Differ in Their Production of Cytokines

Päivi Ekman,1 Marja Saarinen,1 Qiushui He,1,2 Christel Gripenberg-Lerche,1 Alvar Grönberg,3 Heikki Arvilommi,1 and Kaisa Granfors1*

National Public Health Institute, Department in Turku,1 Department of Pediatrics, University of Turku, Turku, Finland,2 Pharmacia & Upjohn AB, Uppsala, Sweden3

Received 25 June 2001/ Returned for modification 15 August 2001/ Accepted 30 November 2001

The cytokine secretion of the Salmonella-permissive, HLA-B27-positive U937 cells was examined, as it was previously shown that these cells kill Salmonella less efficiently than controls. Salmonella-permissive U937 cells showed upregulated production of interleukin 10 and to a lesser extent tumor necrosis factor alpha. HLA-B27-associated modulation of cytokine responses may have importance in the pathogenesis of reactive arthritis.

* Corresponding author. Mailing address: National Public Health Institute, Kiinamyllynkatu 13, FIN-20520 Turku, Finland. Phone: 358-2-2519-255. Fax: 358-2-2519-254. E-mail: Kaisa.Granfors{at}utu.fi.

Infection and Immunity, March 2002, p. 1609-1614, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1609-1614.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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