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Infection and Immunity, March 2002, p. 1623-1626, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1623-1626.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Protective Immunity against Mycobacterium tuberculosis Induced by Dendritic Cells Pulsed with both CD8+- and CD4+-T-Cell Epitopes from Antigen 85A

Helen McShane,* Shahriar Behboudi, Nilu Goonetilleke, Roger Brookes, and Adrian V. S. Hill

Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom

Received 3 July 2001/ Returned for modification 15 August 2001/ Accepted 27 November 2001

Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4+- and CD8+-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4+- or CD8+-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8+ T cells can play a protective role against tuberculosis.

* Corresponding author. Mailing address: Level 7, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. Phone: 44 1865 221609. Fax: 44 1865 221921. E-mail: helen.mcshane{at}ndm.ox.ac.uk.

Infection and Immunity, March 2002, p. 1623-1626, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1623-1626.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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