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Infection and Immunity, March 2002, p. 1627-1630, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1627-1630.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Increased Interleukin 4 (IL-4) Receptor Expression and IL-4-Induced Decrease in IL-12 Production by Langerhans Cells Infected with Leishmania major

Heidrun Moll,1* Anabel Scharner,1,{dagger} and Eckhart Kämpgen2

Institute for Molecular Biology of Infectious Diseases, University of Würzburg, 97070 Würzburg,1 Department of Dermatology, University of Würzburg, 97080 Würzburg, Germany2

Received 27 June 2001/ Returned for modification 15 August 2001/ Accepted 26 November 2001

Langerhans cells (LC) take up Leishmania major and are critical for the induction of the parasite-specific T-cell response. Their functional activities are regulated by cytokines. We analyzed whether infection of LC with L. major modulates the expression of their cytokine receptors. The expression of the interleukin 4 (IL-4) receptor was increased on infected LC from susceptible mice but not on those from resistant mice. Moreover, IL-4 treatment strongly decreased the lipopolysaccharide-induced IL-12 response of infected LC from susceptible mice. This modulation of IL-4 receptor expression and IL-12 production by infection of LC with Leishmania may contribute to the development of Th2 cells and to susceptibility to infection.

* Corresponding author. Mailing address: Institute for Molecular Biology of Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany. Phone: 49 931 31 2627. Fax: 49 931 31 2578. E-mail: h.moll{at}mail.uni-wuerzburg.de.

{dagger} Present address: GSF-Institute for Molecular Immunology, KKG Hyperthermia, Munich, Germany.

Infection and Immunity, March 2002, p. 1627-1630, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1627-1630.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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