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Infection and Immunity, March 2002, p. 1645-1647, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1645-1647.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Selective T-Cell Recognition of the N-Terminal Peptide of GroES in Tuberculosis

Boosbun Chua-Intra,1,{dagger} Robert J. Wilkinson,2 and Juraj Ivanyi1*

MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN,1 Wellcome Centre for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, United Kingdom2

Received 16 July 2001/ Returned for modification 14 September 2001/ Accepted 19 December 2001

Peptides derived from the whole sequence of mycobacterial GroES heat shock proteins were tested for the ability to induce the proliferation of blood mononuclear cells from tuberculosis patients and sensitized healthy subjects. The response to the N-terminal peptide (residues 1 to 16) was found to be more frequent and stronger in tuberculosis patients. This finding is exceptional, considering that recognition of all other GroES peptides by patients was either diminished or not different from that of controls.

* Corresponding author. Mailing address: Department of Oral Medicine & Pathology, 28th Floor Guy's Tower, Guy's Campus of King's College, London SE1 9RT, United Kingdom. Phone: 4420-7950 4568. Fax: 4420-7955 4455. E-mail: juraj.ivanyi{at}kcl.ac.uk.

{dagger} Present address: Leprosy Division, Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand.

Infection and Immunity, March 2002, p. 1645-1647, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1645-1647.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sung, N., Takayama, K., Collins, M. T. (2004). Possible Association of GroES and Antigen 85 Proteins with Heat Resistance of Mycobacterium paratuberculosis. Appl. Environ. Microbiol. 70: 1688-1697 [Abstract] [Full Text]  


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