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Infection and Immunity, March 2002, p. 1648-1652, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1648-1652.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Discordance between T-Cell Receptor Expression and Effector Function in Mice Infected with Histoplasma capsulatum

George S. Deepe, Jr.,* Reta S. Gibbons, and Susan R. Ward

Veterans Affairs Hospital and Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio

Received 10 October 2001/ Returned for modification 13 November 2001/ Accepted 20 November 2001

Vß10+ and Vß14+ T cells were selectively increased 7 to 14 days following infection in the lungs of naive mice infected with Histoplasma capsulatum. Following secondary challenge of immune mice, Vß1+ and Vß8.1+ cells were sporadically increased. Elimination of Vß10+ and Vß14+ cells from naive mice did not alter the course of infection over a period of 21 days. Thus, overexpression of Vß families does not necessarily signify a key role in host defense.

* Corresponding author. Mailing address: Division of Infectious Diseases, Dept. of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0560. Phone: (513) 558-4704. Fax: (513) 558-2089. E-mail: george.deepe{at}uc.edu.

Infection and Immunity, March 2002, p. 1648-1652, Vol. 70, No. 3
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.3.1648-1652.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Heninger, E., Hogan, L. H., Karman, J., Macvilay, S., Hill, B., Woods, J. P., Sandor, M. (2006). Characterization of the Histoplasma capsulatum-Induced Granuloma.. J. Immunol. 177: 3303-3313 [Abstract] [Full Text]  


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