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Infection and Immunity, April 2002, p. 2215-2219, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2215-2219.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

NK T Cells Are a Source of Early Interleukin-4 following Infection with Third-Stage Larvae of the Filarial Nematode Brugia pahangi

Paul Balmer and Eileen Devaney*

Department of Veterinary Parasitology, University of Glasgow, Glasgow G61 1QH, Scotland

Received 4 September 2001/ Returned for modification 1 November 2001/ Accepted 28 November 2001

Infection of C57BL/6 mice with the third-stage larvae of Brugia pahangi results in a rapid expansion of NK1.1+ T cells in the spleen and draining lymph nodes. NK T cells produced interleukin-4 in the spleen within 24 h of infection, and these cells were CD4-.

* Corresponding author. Mailing address: Department of Veterinary Parasitology, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland. Phone: (44) 141-330-5751. Fax: (44) 141-330-5603. E-mail: e.devaney{at}vet.gla.ac.uk.

Editor: W. A. Petri, Jr.

Infection and Immunity, April 2002, p. 2215-2219, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2215-2219.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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