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 Previous Article

Infection and Immunity, April 2002, p. 2245-2248, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2245-2248.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Role of Neisseria meningitidis luxS in Cell-to-Cell Signaling and Bacteremic Infection

Klaus Winzer,1 Yao-hui Sun,2 Andrew Green,1 Marie Delory,2 David Blackley,1 Kim R. Hardie,1 Thomas J. Baldwin,1 and Christoph M. Tang3*

Institute of Infections and Immunity, Queen's Medical Centre, Nottingham NG9 2EX,1 Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College of Technology, Science, and Medicine, London SW7 2AZ,3 Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom2

Received 17 September 2001/ Returned for modification 5 November 2001/ Accepted 15 January 2002

Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.

* Corresponding author. Mailing address: Department of Infectious Diseases, Center for Molecular Microbiology and Infection, Flowers Building, Imperial College of Technology, Science, and Medicine, Armstrong Rd., London SW7 2AZ, United Kingdom. Phone: (44) 207-594-3072. Fax: (44) 207-594-3076. E-mail: c.tang{at}ic.ac.uk.

Editor: V. J. DiRita

Infection and Immunity, April 2002, p. 2245-2248, Vol. 70, No. 4
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.4.2245-2248.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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