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Infection and Immunity, May 2002, p. 2665-2669, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2665-2669.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Cytolethal Distending Toxin of Haemophilus ducreyi Inhibits Endothelial Cell Proliferation

Liselott A. Svensson, Petra Henning, and Teresa Lagergård*

Department of Medical Microbiology and Immunology, Göteborg University, S-4136 Göteborg, Sweden

Received 31 August 2001/ Returned for modification 4 November 2001/ Accepted 29 January 2002

Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits mammalian cell proliferation. We investigated the effects of HdCDT on normal human endothelial cells and on tubule formation in an in vitro model of angiogenesis. Endothelial cells were arrested in the G2 phase of the cell cycle, and tubule formation was inhibited in a dose-dependent manner. The antiproliferative activities of HdCDT on endothelial cells might contribute to the characteristic slow healing and persistence of chancroid ulcers.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Göteborg University, S-4136 Göteborg, Sweden. Phone: 46-31-3424758. Fax: 46-31-820160. E-mail: teresa.lagergard{at}microbio.gu.se.

Editor: A. D. O'Brien

Infection and Immunity, May 2002, p. 2665-2669, Vol. 70, No. 5
0019-9567/02/$04.00+0     DOI: 10.1128/IAI.70.5.2665-2669.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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